公开(公告)号：EP0249257A1

公开(公告)日：1987-12-16

申请号：EP87200684.6

申请日：1987-04-13

Applicant: STAUFFER CHEMICAL COMPANY

Inventor： Leone-Bay, Andrea ,  Bay, William Elliot ,  Timony, Peter Edward

IPC: C07C17/22 ,  C07C25/06 ,  C07C25/08 ,  C07C25/10 ,  C07C25/13 ,  C07C25/22 ,  C07C41/22 ,  C07D213/61 ,  C07D239/30

CPC classification number: C07D239/30 ,  C07B39/00 ,  C07C17/093 ,  C07C41/22 ,  C07D213/61 ,  C07C43/225

Abstract: A process for selectively substituting an aromatic nitro group with a halo group which comprises contacting the nitroaromatic compound with a phosphorushalide of formula: R n PX 5-n wherein n is selected from 0, 1, and 3; R is selected from the group consisting of C-6 to C-10 aryl and substituted aryl wherein the substituents are selected from the group consisting of: straight and branched chain alkyl, alkoxy, and haloalkyl; halogen, sulfonate and mixtures thereof; and X is a halogen in the presence of an arylphosphorusoxydihalide solvent. The use of an arylphosphorustetrahalide and particularly phenylphosphorustetrachloride is preferred. The arylphosphorustetrahalide can be prepared in situ by contacting a solution of the corresponding arylphosphorusdihalide in an arylphosphorusoxydihalide solvent with a halogen. The process can further comprise the step of heating the reaction mixture to maintain a temperature of from about 100°C to about 175°C for from about 1 hour to about 24 hours.

Abstract translation: 一种选择性地用卤素取代芳族硝基的方法，该方法包括使硝基芳族化合物与式RnPX5-n的三卤化磷接触，其中n选自0,1和3; R选自C-6至C-10芳基和取代的芳基，其中取代基选自：直链和支链烷基，烷氧基和卤代烷基; 卤素，磺酸酯及其混合物; X是在芳基磷氧基二卤化物溶剂存在下的卤素。 使用芳基四卤化磷，特别是苯基四氯化磷是优选的。 芳基四卤化磷可通过使相应的芳基二卤化物在芳基磷氧基二卤化物溶剂中的溶液与卤素接触而原位制备。 该方法可以进一步包括加热反应混合物以保持约100℃至约175℃的温度约1小时至约24小时的步骤。