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公开(公告)号：EP0196625B1
公开(公告)日：1992-10-28
申请号：EP86104201.8
申请日：1986-03-26
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Dahod, Samun K. , Siuta-Mangano, Patricia
CPC classification number: C12P41/005 , C12P7/40
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Patent Agency Ranking
公开(公告)号：EP0196625A3
公开(公告)日：1989-03-01
申请号：EP86104201.8
申请日：1986-03-26
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Dahod, Samun K. , Siuta-Mangano, Patricia
CPC classification number: C12P41/005 , C12P7/40
Abstract: Racemic mixtures of partially water-soluble esters defined by the formula
wherein R and R 1 represent hydrogen and C,-C 4 alkyl;
R 2 represents C 1 -C 4 alkyl and X represents halogen, aliphatic or aromatic groups and substituted derivatives thereof wherein R, R 1 and X are different can be resolved by reducing the water solubility of a racemic mixture of said esters by means other than changing the chemical composition of the ester, contacting the racemic mixture of esters of reduced water solubility with a lipase enzyme from Candida cylindracea capable of stereospecifically resolving the racemic mixture by hydrolysis and stereospecifically resolving the racemic mixture.-
3.发明公开Racemization of optically active compounds having a bromine substituted chiral carbon atom 失效含有由溴取代的Chiralkohlenstoffatom旋光活性化合物的外消旋化。
公开(公告)号：EP0216196A2
公开(公告)日：1987-04-01
申请号：EP86112008.7
申请日：1986-08-29
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Dahod, Samun K.
IPC: C07C51/487 , C07C53/19 , C07B55/00
CPC classification number: C07B55/00
Abstract: Optically active compounds having a chlorine atom attached to the chiral carbon atom such as 2-bromoaliphatic acids can be racemized without by-product formation by heating an acidified solution of the organic acid at a temperature sufficient to accomplish racemization, the solution being substantially devoid of ionized halogen other than bromine ions. The preferred acidifying agent is hydrobromic acid. The use of hydrochloric acid causes extensive by-product formation.
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4.发明公开Racemization of optically active compounds having a chlorine substituted chiral carbon atom 失效具有氯化物取代的CHIRAL CARBON ATOM的光学活性化合物的改性
公开(公告)号：EP0214572A3
公开(公告)日：1988-09-28
申请号：EP86112007
申请日：1986-08-29
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Siuta-Mangano, Patricia , Dahod, Samun K.
IPC: C07C51/487 , C07C53/19 , C07B55/00
CPC classification number: C07B55/00
Abstract: Optically active compounds having a chlorine atom attached to the chiral carbon atom such as 2-chloroaliphatic acids can be racemized without by-product formation by heating an acidified solution of the compound in the presence of chloride ion at sufficient strength, and at a pH and temperature sufficient to accomplish racemization. The preferred acidifying agent and source of chloride ion is hydrochloric acid. The use of hydrochloric acid at room temperature as well as the use of either sulfuric acid or caustic soda failed to produce racemization.
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5.发明公开Racemization of optically active compounds having a chlorine substituted chiral carbon atom 失效其含有被氯取代的Chiralkohlenstoffatom otpisch活性化合物的外消旋化。
公开(公告)号：EP0214572A2
公开(公告)日：1987-03-18
申请号：EP86112007.9
申请日：1986-08-29
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Siuta-Mangano, Patricia , Dahod, Samun K.
IPC: C07C51/487 , C07C53/19 , C07B55/00
CPC classification number: C07B55/00
Abstract: Optically active compounds having a chlorine atom attached to the chiral carbon atom such as 2-chloroaliphatic acids can be racemized without by-product formation by heating an acidified solution of the compound in the presence of chloride ion at sufficient strength, and at a pH and temperature sufficient to accomplish racemization. The preferred acidifying agent and source of chloride ion is hydrochloric acid. The use of hydrochloric acid at room temperature as well as the use of either sulfuric acid or caustic soda failed to produce racemization.
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公开(公告)号：EP0196625A2
公开(公告)日：1986-10-08
申请号：EP86104201.8
申请日：1986-03-26
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Dahod, Samun K. , Siuta-Mangano, Patricia
CPC classification number: C12P41/005 , C12P7/40
Abstract: Racemic mixtures of partially water-soluble esters defined by the formula
wherein R and R 1 represent hydrogen and C,-C 4 alkyl;
R 2 represents C 1 -C 4 alkyl and
X represents halogen, aliphatic or aromatic groups and substituted derivatives thereof
wherein R, R 1 and X are different can be resolved by reducing the water solubility of a racemic mixture of said esters by means other than changing the chemical composition of the ester, contacting the racemic mixture of esters of reduced water solubility with a lipase enzyme from Candida cylindracea capable of stereospecifically resolving the racemic mixture by hydrolysis and stereospecifically resolving the racemic mixture.
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