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公开(公告)号：EP0001698A1
公开(公告)日：1979-05-02
申请号：EP78300480.7
申请日：1978-10-10
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Giolito, Silvio Louis , Mirviss, Stanley Burton
Abstract: Normally prepared alkylphenols contain little or no meta-isomer. For many purposes meta-isomers are more desirable than ortho- or para-isomers. 2,6-Dialkylphenols cause colour in phosphate esters made from alkylphenols and are undesirable. The invention reduces these problems by providing a process of isomerisation which increases the proportion of meta-isomer and decreases that of the 2,6-dialkylphenols, in which the alkylphenols are heated with trifluoromethane sulphonic acid. The alkylphenol which is isomerised may be prepared in a first step by reaction of olefin and phenol in the presence of trifluoromethane sulphonic acid. In a two stage process an alkylphenol mixture is prepared by reaction of olefin and phenol in the presence of trifluoromethane sulphonic acid at a concentration 0.01 to 5.0% at a temperature of 120°C to reflux and the mixture so produced is isomerised by maintaining the product at the same temperature to isomerise it.
Abstract translation: 通常制备的烷基酚含有很少或没有间位异构体。 对于许多目的，间位异构体比邻或对位异构体更理想。 2,6-二烷基酚在由烷基酚制成的磷酸酯中引起颜色，是不希望的。 本发明通过提供异构化方法来减少这些问题，其增加了间位异构体的比例并降低了2,6-二烷基酚的比例，其中烷基酚用三氟甲磺酸加热。 异构化的烷基酚可以在第三步中通过烯烃和苯酚在三氟甲烷磺酸的存在下反应来制备。 在两步法中，烷基酚混合物通过烯烃和苯酚在二氯甲烷磺酸存在下，在浓度为0.01至5.0％的温度在120℃至回流的条件下反应来制备，并将如此制备的混合物通过保持产物 在相同的温度下使其异构化。
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公开(公告)号：EP0177072A2
公开(公告)日：1986-04-09
申请号：EP85201318.4
申请日：1985-08-15
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Mirviss, Stanley Burton , Empie, Mark William
IPC: C07C99/08 , C07C101/28 , C07B55/00 , C07B57/00 , C12P13/04
CPC classification number: C12P13/222 , C12P13/04 , C12P41/00
Abstract: Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic or by using zinc and hydrochloric acid followed by hydrolyzing the resultant composition with at least 3 molar equivalents of an alkali metal hydroxide to produce a racemate of an alpha amino acid. The amino acid in suitable derivative form can then be resolved particularly using a two-phase solvent system. The residual isomer of the amino acid remaining after the resolution process can then be racemized using either pyridoxal-5-phosphate or an aliphatic acid in combination with an aldehyde or a ketone. By these procedures, it is possible to obtain high yields of amino acids.
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公开(公告)号：EP0001698B1
公开(公告)日：1981-10-21
申请号：EP78300480.7
申请日：1978-10-10
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Giolito, Silvio Louis , Mirviss, Stanley Burton
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Patent Agency Ranking
公开(公告)号：EP0249359A3
公开(公告)日：1988-12-21
申请号：EP87304671
申请日：1987-05-27
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Mirviss, Stanley Burton
IPC: C07C51/295
CPC classification number: C07C51/295
Abstract: Process for the production of fatty acids by oxidative dehydrogenation of straight or branch chain primary alcohols of from C-4 to C-30 chain lengths per molecule, or mixtures of branch and straight chains, which are selectively reacted with an anhydrous alkali metal hydroxide. In the reaction, the temperature of reaction is gradually increased to maintain the reaction medium in a liquid non-viscous state. The reaction temperature is, however, maintained at a sufficiently low temperature to minimize by-product formation. The process is conducted at temperatures of from about 175°C to about 400°C for sufficient time to form the sodium salt of the acid which is then converted to the acid utilizing a mineral acid.
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公开(公告)号：EP0210683A1
公开(公告)日：1987-02-04
申请号：EP86201150.9
申请日：1986-06-30
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Mirviss, Stanley Burton
IPC: C07D233/76 , C07D233/78 , C07D233/80 , C07C51/36 , C07C67/303 , C07C5/03 , C07C9/15 , C07C13/61 , C07B35/02
CPC classification number: C07D233/72
Abstract: There is disclosed a number of processes for the promotion of the Raney Nickel catalyzed hydrogenation of carbon-carbon double bonds. (a) One process uses tertiary amines to promote the Raney Nickel catalyzed hydrogenation. (b) Another process uses acetylene and acetylene derivatives to promote the Raney Nickel catalyzed hydrogenation. The promotion of Raney Nickel catalyst is particularly suited for the reduction of unsaturated hydantoins to saturated hydantoins and also for the reduction of cyclic and acyclic olefins and diolefins to the corresponding cyclic and acyclic alkanes.
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公开(公告)号：EP0142148A3
公开(公告)日：1985-10-16
申请号：EP84113612
申请日：1984-11-11
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Giolito, Silvio Louis , Mirviss, Stanley Burton
IPC: C07F09/12
CPC classification number: C07F9/12
Abstract: @ Triarylphosphates are prepared by phosphorylation of alkylphenols without use of phosphorylation catalyst. An improved phosphorylation step includes preheating alkylphenol feedstock to 150°C. and completing reaction at 215°C. or above in the presence of a stoichiometric excess of alkylphenol. The absence of phosphorylation catalyst simplifies distillative purification of reaction product by eliminating the need to withdraw purified product as distillate.
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公开(公告)号：EP0177072A3
公开(公告)日：1987-05-27
申请号：EP85201318
申请日：1985-08-15
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Mirviss, Stanley Burton , Empie, Mark William
IPC: C07C99/08 , C07C101/28 , C07B55/00 , C07B57/00 , C12P13/04
CPC classification number: C12P13/222 , C12P13/04 , C12P41/00
Abstract: Amino acids can be easily prepared by reducing unsaturated hydantoins to the corresponding saturated hydantoins by hydrogenating the unsaturated hydantoin using either Raney Nickel catalyst in the presence of more than a stoichiometric amount of caustic or by using zinc and hydrochloric acid followed by hydrolyzing the resultant composition with at least 3 molar equivalents of an alkali metal hydroxide to produce a racemate of an alpha amino acid. The amino acid in suitable derivative form can then be resolved particularly using a two-phase solvent system. The residual isomer of the amino acid remaining after the resolution process can then be racemized using either pyridoxal-5-phosphate or an aliphatic acid in combination with an aldehyde or a ketone. By these procedures, it is possible to obtain high yields of amino acids.
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公开(公告)号：EP0001687A1
公开(公告)日：1979-05-02
申请号：EP78300433.6
申请日：1978-09-29
Applicant: STAUFFER CHEMICAL COMPANY
Inventor： Mirviss, Stanley Burton , Von Lehman, Thomas Michael
IPC: C07F9/20
CPC classification number: C07F9/20
Abstract: In the production of phosphorodichloridothionates difficulties are encountered in purification, In the known processes many impurities result. A multi step process is provided which leads to a substantially pure product. This process comprises chlorinating bis(phosphorothioic)sulphides,thioic acids, or salts thereof, distilling the reaction mixtures, contacting the distillate with a thioic acid or salt thereof, contacting the mixture with water and distilling the organic material after the water contacting. In a representative example dimethyl phosphorochloridothionate is prepared from dimethyl phosphorodithioic acid by chlorination, distillation, reaction of the thionate distillate with dimethyl phosphorodithioc acid to produce a semi-pure thionate reaction mixture which is then contacted with water. The organic layer is then separated and distilled to product an over 99% pure product. The residue is recvcled for reaction with the thioic acid in the first step of the process.
Abstract translation: 在二氯硫代磷酸酯的生产中，在纯化中遇到困难。在已知的方法中产生许多杂质。 提供了一个多步骤的过程，导致产品基本上纯净。 该方法包括氯化双（硫代磷酸）硫化物，硫代酸或其盐，蒸馏反应混合物，使馏出物与硫代酸或其盐接触，使该混合物与水接触并在与水接触后蒸馏有机物质。 在一个代表性实例中，二甲基磷酰氯硫代磷酸酯由二甲基二硫代磷酸通过氯化，蒸馏，硫酸盐馏出物与二甲基二硫代磷酸反应制备半硫酸盐反应混合物，然后与水接触。 然后将有机层分离并蒸馏以产生超过99％的纯产物。 在该方法的第一步骤中，将残留物与硫代酸进行回收。
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