公开(公告)号：EP0098159A2

公开(公告)日：1984-01-11

申请号：EP83303749.2

申请日：1983-06-29

Applicant: STAUFFER CHEMICAL COMPANY

Inventor： Subramanian, N.

IPC: C07F9/38

CPC classification number: C07F9/4006 ,  C07F9/3813

Abstract: A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:

(a) reacting formaldehyde with formamide at a pH of between 9 and 10 to form N-(hydroxymethyl)formamide;
(b) reacting N-(hydroxymethyll formamide with triethyl phosphite to form diethyl, N-(formyl)aminomethylphosphonate:
(c) reacting diethyl, N-(formyllaminomethylphos- phonate with methylchloroacetate to form N-(diethyl- phosphonomethyl), N-(formyl)glycinemethyl ester; and
(d) reacting N-(diethylphosphonomethyl) N-(formyl). glycine methyl ester with a hydrolyzing agent to form N-phosphonomethylglycine is disclosed.

A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:

(a) reacting an aminomethylphosphonate corresponding to the following general formula:
wherein R represents formyl, acetyl, methoxycarbonyl, phenyloxycarbonyl or benzyl; and R' represents methyl, ethyl, propyl, butyl, pentyl or hexyl; with methylchloroacetate in the presence of an organic solvent and a proton- extracing base to form as an intermediate product, N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester; and
(b) reacting the N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester with a hydrolyzing agent to cause formation of N-phosphonomethylglycine is also disclosed.

Thus, the production of a valuable herbicide is improved.

Abstract translation: 一种制备N-膦酰基甲基甘氨酸的方法，其特征在于它包括：（a）使甲醛与甲酰胺在pH9至10之间反应形成N-（羟甲基）甲酰胺;（b）使N-（羟甲基） 甲酰胺与亚磷酸三乙酯反应形成二乙基，N-（甲酰基）氨基甲基膦酸酯;（c）使二乙基，N-（甲酰基）氨基甲基膦酸酯与氯乙酸甲酯反应形成N-（二乙基膦酰基甲基） 和（d）使N-（二乙基膦酰基甲基）N-（甲酰基） - 甘氨酸甲酯与水解剂反应形成N-膦酰基甲基甘氨酸。 一种制备N-膦酰基甲基甘氨酸的方法，其特征在于它包括：（a）使与下列通式相应的氨基甲基膦酸酯反应：R-NH-CH 2 - （ - OR）2 ... 其中R表示甲酰基，乙酰基，甲氧基羰基，苯氧基羰基或苄基; R min表示甲基，乙基，丙基，丁基，戊基或己基; 与甲基氯乙酸酯在有机溶剂和质子引发碱的存在下形成中间产物，N-（二烷基膦酰基甲基），N-（取代的）甘氨甲酯; 和（b）还公开了N-（二烷基膦酰基甲基），N-（取代的）甘氨甲酯与水解剂反应以形成N-膦酰基甲基甘氨酸。 因此，有益的除草剂的生产得到改善。

公开(公告)号：EP0098159B1

公开(公告)日：1986-09-03

申请号：EP83303749.2

申请日：1983-06-29

Applicant: STAUFFER CHEMICAL COMPANY

Inventor： Subramanian, N.

IPC: C07F9/38

CPC classification number: C07F9/4006 ,  C07F9/3813

公开(公告)号：EP0098159A3

公开(公告)日：1984-03-21

申请号：EP83303749

申请日：1983-06-29

Applicant: STAUFFER CHEMICAL COMPANY

Inventor： Subramanian, N.

IPC: C07F09/38 ,  C07F09/40

CPC classification number: C07F9/4006 ,  C07F9/3813

Abstract: A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:
(a) reacting formaldehyde with formamide at a pH of between 9 and 10 to form N-(hydroxymethyl)formamide; (b) reacting N-(hydroxymethyll formamide with triethyl phosphite to form diethyl, N-(formyl)aminomethylphosphonate: (c) reacting diethyl, N-(formyllaminomethylphos- phonate with methylchloroacetate to form N-(diethyl- phosphonomethyl), N-(formyl)glycinemethyl ester; and (d) reacting N-(diethylphosphonomethyl) N-(formyl). glycine methyl ester with a hydrolyzing agent to form N-phosphonomethylglycine is disclosed. A process for the preparation of N-phosphonomethylglycine characterised in that it comprises:
(a) reacting an aminomethylphosphonate corresponding to the following general formula:
wherein R represents formyl, acetyl, methoxycarbonyl, phenyloxycarbonyl or benzyl; and R' represents methyl, ethyl, propyl, butyl, pentyl or hexyl; with methylchloroacetate in the presence of an organic solvent and a proton- extracing base to form as an intermediate product, N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester; and (b) reacting the N-(dialkylphosphonomethyl), N-(substituted)glycinemethyl ester with a hydrolyzing agent to cause formation of N-phosphonomethylglycine is also disclosed. Thus, the production of a valuable herbicide is improved.