公开(公告)号：WO2018023108A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/044619

申请日：2017-07-31

Applicant: STC. UNM

Inventor： DERETIC, Vojo

IPC: A61K31/70 ,  A61K38/21 ,  A61P31/04 ,  A61P35/00

CPC classification number: A61K31/702 ,  A61K31/05 ,  A61K31/137 ,  A61K31/155 ,  A61K31/436 ,  A61K31/4375 ,  A61K31/616 ,  A61K31/7016 ,  A61K38/21 ,  A61K45/06 ,  A61P35/00 ,  A61K2300/00

Abstract: Tie present invention relates to compositions and methods of influencing autophagy by modulating TRIM (tripartite motif containing) proteins, especially TRIM 8, TRIM: 10, TRIM 16, TRIM 19 and/or TRI.M 51 (preferably TRIM 16} and galectins, especially galectins 3 m order to influence authophagy and treat a number of disease states and/or conditions which are mediated and/or influenced by autophagy, including inflammatory disease states and/or conditions, including a microbial infection such as a Mycobacterium infection, among numerous others, an inflammatory disorder, a lysosomal, storage disorder, an immune disorder, a neurodegenerative disorder and a cancer.

Abstract translation: 本发明涉及通过调节TRIM（含三联基序）蛋白质，尤其是TRIM 8，TRIM：10，TRIM 16，TRIM 19和/或TRI.M 51（ 优选TRIM 16}和半乳糖凝集素，特别是半乳凝素3以影响自体吞噬并治疗许多由自噬介导和/或影响的疾病状态和/或病症，包括炎性疾病状态和/或病症，包括微生物感染 作为分枝杆菌感染，在许多其他疾病中，炎性疾病，溶酶体，储存病症，免疫病症，神经退行性病症和癌症。