公开(公告)号：WO2017136400A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/015960

申请日：2017-02-01

Applicant: STC. UNM

Inventor： HALL, Pamela ,  CHACKERIAN, Bryce ,  PEABODY, David, S. ,  DALY, Seth, Michael ,  ELMORE, Brad ,  TRIPLETT, Kathleen

IPC: A61K39/085 ,  A61P31/04 ,  A61P37/04

CPC classification number: A61K39/085 ,  A61K2039/5258 ,  C12N2795/18123

Abstract: The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

Abstract translation: 本发明涉及经改造以呈递来自金黄色葡萄球菌（SA）的表位的病毒样颗粒（VLP），优选自体诱导肽（AIP），其调节该病原体中的群体感应依赖性毒力 ，或来自SA毒素和白细胞杀伤素的表位。 这些VLP可用于提供免疫原性组合物和有效疫苗。 在SA皮肤坏死的小鼠模型中，接种含AIP的VLP或含SA毒素的VLP诱导保护性免疫以限制SA感染的发病机理并促进细菌清除。