公开(公告)号：WO2017123492A1

公开(公告)日：2017-07-20

申请号：PCT/US2017/012687

申请日：2017-01-09

Applicant: STC. UNM

Inventor： HALL, Pamela ,  PROSSNITZ, Eric, R. ,  HATHAWAY, Helen, J.

IPC: A61K38/17 ,  C07K14/47 ,  A61K31/138

CPC classification number: A61K35/644 ,  A61K31/4741 ,  A61K38/14 ,  A61K45/06 ,  C07K14/70567 ,  A61K2300/00

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition -and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bac terial pathogens, including MRSA are also described.

Abstract translation: 本发明涉及作为G蛋白偶联雌激素受体（GPER）的调节剂的化合物用于抑制和/或治疗细菌感染，尤其包括metMctHin抗性 （金黄色葡萄球菌）（MRSA）感染。 还描述了包括MRSA在内的细菌病原体的药物组合物和治疗方法。