公开(公告)号：WO2019210033A1

公开(公告)日：2019-10-31

申请号：PCT/US2019/029065

申请日：2019-04-25

Applicant: STC. UNM ,  MELLIOS, Nikolaos

Inventor： STC. UNM ,  MELLIOS, Nikolaos

IPC: C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6876

Abstract: A plurality of circular RNAs (circRNAs) the expression of which is correlated with brain disorders. The circRNAs are useful for compositions, kits, assays, and methods for the identification, diagnosis, screening, treatment and/or monitoring of brain disorders including psychiatric disorders such as bipolar disorder (BD), schizophrenia (SCZ), depression, Attention- Deficit/Hyperactivity Disorder (ADHD), Obsessive-compulsive disorder (OCD), Anxiety Disorders, etc., and neurodevelopmental disorders such as Autism, Asperger's Syndrome, and other Autism Spectrum Disorders (ASD), pervasive developmental disorders not otherwise specified (PDD-NOS), etc.

公开(公告)号：WO2022192914A1

公开(公告)日：2022-09-15

申请号：PCT/US2022/071110

申请日：2022-03-11

Applicant: MELLIOS, Nikolaos ,  HAFEZ, Alexander K. ,  TRIVEDI, Madhukar H.

Inventor： MELLIOS, Nikolaos ,  HAFEZ, Alexander K.

IPC: C12N15/113 ,  C12N15/10 ,  C12N9/22 ,  C12N15/63 ,  A01K67/027

Abstract: A method for disrupting the formation of circular RNAs in vivo, by disrupting or removing one or more intronic regulatory sequences responsible for circRNA backsplicing. The systems and methods can further be used for inhibiting the expression of therapeutically relevant circular RNAs in vivo related to brain and other disorders, as well as the creation of transgenic animal having one or more circRNA mutations that can be used as models mammalian diseases related to circRNA production and regulation, and in particular human brain disorders.

公开(公告)号：WO2022183011A1

公开(公告)日：2022-09-01

申请号：PCT/US2022/017936

申请日：2022-02-25

Applicant: MELLIOS, Nikolaos ,  TRIVEDI, Madhukar H.

Inventor： MELLIOS, Nikolaos ,  TRIVEDI, Madhukar H.

IPC: C12N15/113 ,  C12Q1/6876 ,  A61P25/24 ,  C12Q1/6874 ,  A61K45/06 ,  C12Q1/6844 ,  A61P25/18 ,  C12Q1/6883 ,  C12Q2600/178

Abstract: A plurality of circular RNAs (circRNAs) the expression of which is correlated with diagnosis for Major Depressive Disorder (MDD) and Bipolar Disorder (BD) and response to treatment with various antidepressants is provided. The circRNAs are useful for compositions, kits, assays, and methods for the identification, diagnosis, screening, treatment, and/or monitoring of brain disorders such as MDD and BD.