公开(公告)号：WO2016172173A1

公开(公告)日：2016-10-27

申请号：PCT/US2016/028388

申请日：2016-04-20

Applicant: STC.UNM ,  SHREVE, Andrew, P. ,  GRAVES, Steven, Wayde ,  EDWARDS, Bruce, S. ,  JUAREZ, Jaime, Javier

Inventor： SHREVE, Andrew, P. ,  GRAVES, Steven, Wayde ,  EDWARDS, Bruce, S. ,  JUAREZ, Jaime, Javier

IPC: G01B9/02

CPC classification number: G01N21/6486 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J2003/2826 ,  G01N15/0211 ,  G01N15/14 ,  G01N15/147 ,  G01N2015/1006

Abstract: A method to simultaneously detect emission intensity or images at multiple distinct emission wavelengths in the analysis of parallel sample streams in a flow-based analysis system and apparatus for performing the described method.

Abstract translation: 在基于流的分析系统和用于执行所描述的方法的装置中，在平行样本流的分析中同时检测发射强度或多个不同发射波长的图像的方法。

公开(公告)号：EP2864762A1

公开(公告)日：2015-04-29

申请号：EP13807610.4

申请日：2013-03-15

Applicant: STC.UNM

Inventor： GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

IPC: G01N15/14 ,  G01N21/27 ,  C12Q1/02

CPC classification number: G01N15/1404 ,  G01N15/1459 ,  G01N2015/142

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

公开(公告)号：WO2013191772A1

公开(公告)日：2013-12-27

申请号：PCT/US2013/032025

申请日：2013-03-15

Applicant: STC.UNM ,  GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

Inventor： GRAVES, Steven, Wayde ,  AUSTIN SUTHANTHIRARA, Pearlson, Prashanth ,  SHREVE, Andrew, P. ,  LOPEZ, Gabriel, P.

IPC: G01N15/14 ,  G01N21/27 ,  C12Q1/02

CPC classification number: G01N15/1404 ,  G01N15/1459 ,  G01N2015/142

Abstract: An affordable flow cytometry system with a significantly increased analytical rate, volumetric sample delivery and usable particle size including a light beam that interrogates multiple flow streams so as to provide excitation across all of the streams, and an optical objective configured to collect light from the sample streams and image the light onto an array detector.

Abstract translation: 一种负担得起的流式细胞仪系统，具有显着增加的分析速率，体积样品输送和可用的粒度，包括询问多个流动流的光束，以便在所有流中提供激发;以及光学物镜，被配置为收集来自样品的光 流并将光成像到阵列检测器上。

公开(公告)号：WO2015179619A1

公开(公告)日：2015-11-26

申请号：PCT/US2015/031938

申请日：2015-05-21

Applicant: STC.UNM ,  BROWN III, Carl ,  GRAVES, Steven, Wayde ,  STEFANOVIC, Darko ,  LAKIN, Matthew, Richard

Inventor： BROWN III, Carl ,  GRAVES, Steven, Wayde ,  STEFANOVIC, Darko ,  LAKIN, Matthew, Richard

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12Q1/6816 ,  C12Q2521/345 ,  C12Q2525/301 ,  C12Q2565/1015

Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

Abstract translation: 本公开描述了结构化多核苷酸，包括结构化多核苷酸的装置和涉及结构化多核苷酸和/或装置的方法。 通常，结构化多核苷酸包括五个结构域。 第一个域用作输入DNA逻辑门的始发点，以启动与SCS生物分子的结合。 第二个域用作上游DNA逻辑门的底物识别序列。 第三个域用作输出DNA逻辑门的脚注，以启动SCS生物分子与门的结合。 第四个域用作效应序列来改变输出逻辑门的状态。 第五结构域充当笼状序列，以将效应序列锁定在无活性状态，直到输入门结合结构化多核苷酸。