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公开(公告)号：WO2015023830A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/051025
申请日：2014-08-14
Applicant: STC.UNM
Inventor： HILL, Jeff, Wade
IPC: A61K31/135 , A61K31/045 , A61K31/085
CPC classification number: A61K31/138 , A61K9/0019 , A61K31/27 , A61K31/325 , A61K45/06 , G01N33/5058 , A61K2300/00
Abstract: Using high-throughput screening, in an oxygen-glucose deprivation (OGD) model, isoxsuprine hydrochloride was identified as a potent neuroprotective compound. In an animal middle artery occlusion (MCAO) model of transient focal ischemia, isoxsuprine significantly reduced infarct volume compared to vehicle. The invention, therefore, provides methods of treatment and pharmaceutical compositions that are useful in the treatment and prevention of a wide-variety of ischemia-related injuries, including stroke.
Abstract translation: 使用高通量筛选，在氧 - 葡萄糖剥夺（OGD）模型中，将isoxsuprine盐酸盐鉴定为有效的神经保护性化合物。 在短暂性局灶性缺血的动物中动脉闭塞（MCAO）模型中，与载体相比，isoxsuprine显着降低了梗死体积。 因此，本发明提供了治疗和药物组合物的方法，其可用于治疗和预防各种与缺血相关的损伤，包括中风。
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公开(公告)号：WO2015077763A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/067356
申请日：2014-11-25
Applicant: STC.UNM
Inventor： HILL, Jeff, Wade
CPC classification number: A61K38/06 , A61K38/00 , A61K45/06 , C07K5/0823 , C07K14/7158
Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.
Abstract translation: 本发明提供了一种基于CXCR拮抗肽的新型药物。 除其他之外，本发明提供用于治疗涉及CXCR介导的途径的疾病，病症和病症的肽，组合物和方法。 提供了有效治疗炎症，中风，创伤性脑损伤，胰腺癌等的组合物和方法。
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