公开(公告)号：EP2616485A2

公开(公告)日：2013-07-24

申请号：EP11825972.0

申请日：2011-09-15

Applicant: STC.UNM

Inventor： PAUL, Surojit

IPC: C07K14/47 ,  C07K19/00 ,  A61K38/17 ,  A61P25/00

CPC classification number: C12N9/16 ,  A61K38/00 ,  A61K38/465 ,  C12Y301/03048

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

公开(公告)号：WO2012037397A3

公开(公告)日：2012-03-22

申请号：PCT/US2011/051827

申请日：2011-09-15

Applicant: STC.UNM ,  PAUL, Surojit

Inventor： PAUL, Surojit

IPC: C07K14/47 ,  C07K19/00 ,  A61K38/17 ,  A61P25/00

Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

公开(公告)号：WO2020014102A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/040769

申请日：2019-07-08

Applicant: STC.UNM ,  PODDAR, Ranjana ,  PAUL, Surojit

Inventor： PODDAR, Ranjana ,  PAUL, Surojit

IPC: A61K31/498 ,  A61P25/00 ,  A61P3/00

Abstract: A method for treating a hyperhomocysteinemic subject having cerebral ischemic stroke generally includes administering to the hyperhomocysteinemic subject, following cerebral stroke, a composition that includes an inhibitor or an antagonist of a GluN2A-containing N-methyl-D-aspartate receptor (NMDAR) in an amount effective to ameliorate at least one symptom or clinical sign of cerebral stroke.