公开(公告)号：EP1993645A2

公开(公告)日：2008-11-26

申请号：EP07752039.3

申请日：2007-03-01

Applicant: STC.UNM

Inventor： SMYTH, Hugh ,  TRUMAN, Charles, Randall

IPC: A61M15/00

CPC classification number: A61M15/0065 ,  A61M15/0003 ,  A61M15/001 ,  A61M15/0028 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0068 ,  A61M2202/064 ,  A61M2205/8275 ,  A61M2206/14 ,  A61M2206/16

Abstract: The present invention comprises a dry powder inhaler (DPI) that uses a patient's inhalation flow to concentrate energy in an aeroelastic element for deaggregation and dispersion of a powder dose. The result is a DPI that delivers a dose independent of inspiratory abilities of the patient, solving a major problem of conventional DPIs. Increased tension on the aeroelastic element causes higher frequency vibrations and improved powder dispersion. The tension of the aeroelastic element can be modified prior to dispensing the DPI to the patient, allowing for individualization for single patients or groups of patients. In addition, the DPI has features that increase the turbulence of the airflow as it passes through the device, further increasing the dispersion and deaggregation of the powder. The DPI can hold a single dose or multiple doses. The powder doses can be dispensed directly onto the aeroelastic element, or may be in adjacent blister packaging.

公开(公告)号：WO2007103152A2

公开(公告)日：2007-09-13

申请号：PCT/US2007/005312

申请日：2007-03-01

Applicant: STC.UNM ,  SMYTH, Hugh ,  TRUMAN, Charles, Randall

Inventor： SMYTH, Hugh ,  TRUMAN, Charles, Randall

IPC: A61M15/00 ,  A61M16/10

CPC classification number: A61M15/0065 ,  A61M15/0003 ,  A61M15/001 ,  A61M15/0028 ,  A61M15/0043 ,  A61M15/0045 ,  A61M15/0051 ,  A61M15/0055 ,  A61M15/0068 ,  A61M2202/064 ,  A61M2205/8275 ,  A61M2206/14 ,  A61M2206/16

Abstract: The present invention comprises a dry powder inhaler (DPI) that uses a patient's inhalation flow to concentrate energy in an aeroelastic element for deaggregation and dispersion of a powder dose. The result is a DPI that delivers a dose independent of inspiratory abilities of the patient, solving a major problem of conventional DPIs. Increased tension on the aeroelastic element causes higher frequency vibrations and improved powder dispersion. The tension of the aeroelastic element can be modified prior to dispensing the DPI to the patient, allowing for individualization for single patients or groups of patients. In addition, the DPI has features that increase the turbulence of the airflow as it passes through the device, further increasing the dispersion and deaggregation of the powder. The DPI can hold a single dose or multiple doses. The powder doses can be dispensed directly onto the aeroelastic element, or may be in adjacent blister packaging.

Abstract translation: 本发明包括干粉吸入器（DPI），其使用患者的吸入流将能量集中在气动弹性元件中用于粉末剂量的解聚和分散。 其结果是DPI能够独立于患者的吸气能力，解决常规DPI的主要问题。 气动弹性元件上的增加的张力会导致更高的频率振动和改善的粉末分散。 在将DPI分配给患者之前，可以修改气动弹性元件的张力，从而允许单个患者或患者组的个体化。 此外，DPI具有增加气流在通过装置时的湍流的特征，进一步增加了粉末的分散和解聚。 DPI可以持续单剂量或多剂量。 粉末剂量可以直接分配到气动弹性元件上，或者可以在相邻的吸塑包装中。

公开(公告)号：WO2012148953A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/034882

申请日：2012-04-25

Applicant: STC.UNM ,  SMYTH, Hugh ,  EL-SHERBINY, Ibrahim M.

Inventor： SMYTH, Hugh ,  EL-SHERBINY, Ibrahim M.

IPC: A61K9/14 ,  A61M31/00

CPC classification number: A61K47/48923 ,  A61K9/0075 ,  A61K9/5161 ,  A61K31/496

Abstract: The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.

Abstract translation: 本发明涉及可适用于向受试者施用治疗剂的固体组合物。 本发明还涉及制备这种固体组合物的方法。 本发明还涉及通过向受试者施用这种固体组合物来治疗疾病，病症或病症的方法。