公开(公告)号：WO2016019311A1

公开(公告)日：2016-02-04

申请号：PCT/US2015/043240

申请日：2015-07-31

Applicant: STC.UNM ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

Inventor： SALAMEH, Ahmed ,  LEE, Alessandro ,  NUNES, Diana, N. ,  DIAD-NETO, Emmanuel ,  PASQUALINE, Renata ,  ARAP, Wadih

IPC: A61K31/7088

CPC classification number: A61K31/7088

Abstract: Methods for detecting and treating prostate cancers are provided. In some aspects, methods for detecting a prostate cancer comprise measuring a level of PRUNE2 expression and/or PCA3 expression in a sample from a subject. In further aspects, a method for treating prostate cancer is provided comprising administering a PRUNE2 tumor suppressor polypeptide or a nucleic acid molecule that inhibits expression of PC A3 RNA.

Abstract translation: 提供了检测和治疗前列腺癌的方法。 在一些方面，用于检测前列腺癌的方法包括测量来自受试者的样品中PRUNE2表达和/或PCA3表达的水平。 在另外的方面，提供了一种治疗前列腺癌的方法，包括施用PRUNE2肿瘤抑制多肽或抑制PC A3 RNA表达的核酸分子。

公开(公告)号：WO2018057703A1

公开(公告)日：2018-03-29

申请号：PCT/US2017/052661

申请日：2017-09-21

Applicant: STC.UNM ,  LOS ALAMOS NATIONAL SECURITY, LLC

Inventor： PASQUALINI, Renata ,  ARAP, Wadih ,  STAQUICINI, Fernanda, Iamassaki ,  FERRARA, Fortunato ,  D'ANGELO, Sara ,  BRADBURY, Andrew, R. M.

IPC: C07K16/28 ,  C12N15/13 ,  C12N15/63 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61K38/07 ,  A61K39/3955 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6849 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/77 ,  C12N15/1037 ,  G01N33/57423

Abstract: Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.

Abstract translation: 提供了分离的或重组的Eph A5或GRP78靶向抗体。 在一些情况下，实施方案的抗体可用于检测，诊断和/或治疗人类疾病，例如癌症。 还提供了使用体外和体内方法的组合快速鉴定用于治疗癌症的抗体或抗体片段的方法。