公开(公告)号：US20150250905A1

公开(公告)日：2015-09-10

申请号：US14428350

申请日：2013-09-14

Applicant: STICHTING KATHOLIEKE UNIVERSITEIT

Inventor： Carl Gustav Figdor ,  Ingrid Jolanda Monique De Vries ,  Mangala Srinivas ,  Luis Javier Cruz Ricondo

IPC: A61K49/22

CPC classification number: A61K49/225 ,  A61K49/0002 ,  A61K49/0034 ,  A61K49/0093 ,  A61K49/1818 ,  A61K49/221

Abstract: The present invention relates to contrast agent enhanced medical ultrasound imaging. In particular, the contrast agents provided are useful for cell imaging and cell therapy, as well as in vivo targeting, drug delivery and perfusion or vascular imaging applications. More specifically, it provides a particle comprising a fluorinated organic compound and a metal. Such particles may be advantageously employed in qualitative or quantitative imaging such as acoustic imaging including photoacoustic and ultra-sound imaging, MRI imaging, such as 19F imaging, 1H imaging including T1 and T2 weighted imaging, SPECT, PET, scintigraphy, fluorescence imaging and optical coherence imaging and tomographic applications. This may then be employed in cell labeling, microscopy, histology or for imaging vasculature or perfusion in vivo and in vitro.

Abstract translation: 本发明涉及造影剂增强医学超声成像。 特别地，提供的造影剂可用于细胞成像和细胞治疗，以及体内靶向，药物递送和灌注或血管成像应用。 更具体地，它提供了包含氟化有机化合物和金属的颗粒。 这样的颗粒可以有利地用于定性或定量成像，例如包括光声和超声成像的声学成像，MRI成像，例如19F成像，包括T1和T2加权成像的1H成像，SPECT，PET，闪烁扫描，荧光成像和光学 相干成像和断层摄影应用。 然后可以将其用于体内和体外的细胞标记，显微镜，组织学或成像脉管系统或灌注成像。