公开(公告)号：WO2014007629A1

公开(公告)日：2014-01-09

申请号：PCT/NL2013/050497

申请日：2013-07-04

Applicant: STICHTING VU-VUMC

Inventor： CHRISTIAANS, Johannes Antonius Maria ,  WINDHORST, Albert Dirk ,  METAXAS, Athanasios ,  KLEIN, Pieter Jacob ,  KOOIJMAN, Esther Johanna Maria ,  VAN BERCKEL, Bart Nicolaas Maria

IPC: C07C217/56 ,  C07D213/24

CPC classification number: C07D213/74 ,  C07C213/02 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/24 ,  C07D213/38 ,  C07C215/74

Abstract: The invention is directed to a compound according to formula (1) wherein R 2 is fluorine, X is nitrogen or carbon and R 3 is an organic group. The invention is also directed to the use of this compound as a precursor for the preparation of a 11 C or 18 F-radio labelled compound. The radio labelled compound may be used in an in vivo diagnostic or imaging method.

Abstract translation: 本发明涉及式（1）的化合物，其中R 2是氟，X是氮或碳，R 3是有机基团。 本发明还涉及该化合物作为制备11C或18F-无线电标记化合物的前体的用途。 放射性标记的化合物可以用于体内诊断或成像方法。

公开(公告)号：WO2012165956A1

公开(公告)日：2012-12-06

申请号：PCT/NL2012/050377

申请日：2012-05-30

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG ,  STICHTING VU-VUMC ,  KLEIN, Pieter Jacob ,  METAXAS, Athansios ,  WINDHORST, Albert Dirk ,  CHRISTIAANS, Johannes Antonius Maria ,  VAN BERCKEL, Bart Nicolaas Maria

Inventor： KLEIN, Pieter Jacob ,  METAXAS, Athansios ,  WINDHORST, Albert Dirk ,  CHRISTIAANS, Johannes Antonius Maria ,  VAN BERCKEL, Bart Nicolaas Maria

IPC: C07C279/18 ,  C07B59/00 ,  A61K31/155

CPC classification number: C07C279/18 ,  A61K31/155 ,  A61K51/04 ,  C07B59/001 ,  C07B2200/05 ,  C07C277/08 ,  C07C319/20 ,  C07C323/44

Abstract: The invention is directed to a N, N-substituted guanidine compound or a salt or solvate thereof according to formula (1), R 1 RNC(NH)NR 2 R 3 , wherein R 1 is methyl and R 2 is hydrogen. R 3 is a organic group comprising a halogen and thiomethyl substituted phenyl group. R is an organic group comprising a substituted aryl group Z wherein the substituent group is -Y-R 4 , wherein Y is a heteroatom chosen from the group consisting of O, S and N and R 4 is a fluorinated organic group.

Abstract translation: 本发明涉及根据式（1）的R1，R2，R2是氢的N，N-取代的胍化合物或其盐或溶剂合物，R1RNC（NH）NR2R3。 R3是包含卤素和硫代甲基取代的苯基的有机基团。 R是包含取代的芳基Z的有机基团，其中取代基是-Y-R 4，其中Y是选自O，S和N的杂原子，R4是氟化有机基团。

公开(公告)号：EP2867200A1

公开(公告)日：2015-05-06

申请号：EP13739857.4

申请日：2013-07-04

Applicant: Stichting VU-VUmc

Inventor： CHRISTIAANS, Johannes Antonius Maria ,  WINDHORST, Albert Dirk ,  METAXAS, Athanasios ,  KLEIN, Pieter Jacob ,  KOOIJMAN, Esther Johanna Maria ,  VAN BERCKEL, Bart Nicolaas Maria

IPC: C07C217/56 ,  C07D213/24

CPC classification number: C07D213/74 ,  C07C213/02 ,  C07C2601/02 ,  C07C2601/08 ,  C07D213/24 ,  C07D213/38 ,  C07C215/74

Abstract: The invention is directed to a compound according to formula (1) wherein R
2 is fluorine, X is nitrogen or carbon and R
3 is an organic group. The invention is also directed to the use of this compound as a precursor for the preparation of a
11 C or
18 F-radio labelled compound. The radio labelled compound may be used in an in vivo diagnostic or imaging method.

Abstract translation: 本发明涉及式（1）的化合物，其中R 2是氟，X是氮或碳，R 3是有机基团。 本发明还涉及该化合物作为制备11C或18F-无线电标记化合物的前体的用途。 放射性标记的化合物可以用于体内诊断或成像方法。