公开(公告)号：NL2015814B1

公开(公告)日：2017-06-06

申请号：NL2015814

申请日：2015-11-19

Applicant: STICHTING VU-VUMC

Inventor： GYDO VAN DER HEIJDEN ,  JACOBUS ADRIANUS WILHELMUS JONG ,  ROMANO VINCENZO ANTONIO ORRU ,  EELCO RUIJTER

IPC: C07D213/72 ,  C07D213/75

Abstract: The present invention provide novel substituted 2-isocyanopyridines and their use in methods comprising reacting substituted isocyanopyridines of the general formula with a carbonyl-containing compound selected from the group consisting of an aldehyde and a ketone; in the presence of an acidic carbon compound selected from the group consisting of a carboxylic acid and a (thio)phenolic compound and/or a primary or secondary amine, including their use in Ugi, Passerini and Ugi-Smiles reactions, and conversion of the resulting secondary amide products to (thio)carboxylic acids, (thio)esters and amides.