公开(公告)号：WO2014129895A1

公开(公告)日：2014-08-28

申请号：PCT/NL2014/050102

申请日：2014-02-19

Applicant: STICHTING VU-VUMC

Inventor： VAN BEUSECHEM, Victor Willem ,  HODZIC, Jasmina

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: The invention relates to the use of a gene or a gene product as a target for identifying a pharmacologically active compound, preferably for sensitizing a cancer cell for ionizing radiation. The invention further relates to methods for determining whether a compound is capable of sensitizing a cancer cell for ionizing radiation and to methods for increasing the susceptibility of a cell to radiation. Additionally, the invention related to a compound for use in the treatment of an individual suffering from cancer, preferably wherein said treatment comprises irradiating said individual or part thereof with ionizing radiation. Furthermore, the invention relates to methods for determining the radiation sensitivity of a cancer in an individual. The preferred target of radiosensitization is GPR27.

Abstract translation: 本发明涉及基因或基因产物作为鉴定药理学活性化合物的靶的用途，优选用于敏化用于电离辐射的癌细胞。 本发明还涉及用于确定化合物是否能够致敏癌细胞以进行电离辐射的方法以及用于增加细胞对辐射的敏感性的方法。 此外，本发明涉及用于治疗患有癌症的个体的化合物，优选其中所述治疗包括用电离辐射照射所述个体或其部分。 此外，本发明涉及用于确定个体中癌症的辐射敏感性的方法。 辐射敏化的首选目标是GPR27。