公开(公告)号：WO2015165779A2

公开(公告)日：2015-11-05

申请号：PCT/EP2015/058614

申请日：2015-04-21

Applicant: STICHTING VU-VUMC ,  UNIVERSIDAD DE GRANADA

Inventor： PEGTEL, Dirk Michiel ,  KOPPERS-LALIC, Danijela ,  WURDINGER, Tom ,  BIJNSDORP, Irene ,  HACKENBERG, Michael

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  A61K31/166 ,  A61K31/475 ,  A61K31/573 ,  A61K31/675 ,  A61K31/704 ,  A61K31/7048 ,  A61K35/545 ,  A61K38/14 ,  C12Q1/6809 ,  C12Q2600/118 ,  C12Q2600/178 ,  C12Q2525/207 ,  C12Q2535/122 ,  C12Q2537/165 ,  C12Q2545/101

Abstract: The present disclosure provides small ncRNAs as biomarkers for classifying the health status of an individual. The disclosure also provides screening methods for identifying ncRNA biomarkers.

Abstract translation: 本公开提供小的ncRNA作为用于分类个体的健康状况的生物标志物。 本公开还提供用于鉴定ncRNA生物标志物的筛选方法。

公开(公告)号：WO2014025254A1

公开(公告)日：2014-02-13

申请号：PCT/NL2013/050581

申请日：2013-08-06

Applicant: STICHTING VU-VUMC

Inventor： PEGTEL, Dirk Michiel

IPC: C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/6883 ,  C12Q1/686 ,  C12Q1/705

Abstract: The present invention relates to an in vitro method for diagnosis and/or determining severity of Systemic Lupus Erythematosus. The method determines presence and/or quantity of at least one EBV marker, preferably EBV-EBER and/or antibody against EBV antigen, in a sample obtained from a subject. The method may further be used to discriminate between Systemic Lupus Erythematosus, and rheumatoid arthritis.

Abstract translation: 本发明涉及用于诊断和/或确定系统性红斑狼疮严重性的体外方法。 该方法在从受试者获得的样品中确定至少一种EBV标志物，优选EBV-EBER和/或抗EBV抗原抗体的存在和/或量。 该方法还可用于区分系统性红斑狼疮和类风湿性关节炎。

公开(公告)号：WO2014025254A9

公开(公告)日：2014-02-13

申请号：PCT/NL2013/050581

申请日：2013-08-06

Applicant: STICHTING VU-VUMC

Inventor： PEGTEL, Dirk Michiel

IPC: C12Q1/68 ,  C12Q1/70

Abstract: The present invention relates to an in vitro method for diagnosis and/or determining severity of Systemic Lupus Erythematosus. The method determines presence and/or quantity of at least one EBV marker, preferably EBV-EBER and/or antibody against EBV antigen, in a sample obtained from a subject. The method may further be used to discriminate between Systemic Lupus Erythematosus, and rheumatoid arthritis.