公开(公告)号：WO2014171826A1

公开(公告)日：2014-10-23

申请号：PCT/NL2014/050242

申请日：2014-04-17

Applicant: STICHTING VU-VUMC

Inventor： SMIT, August Benjamin ,  SPIJKER, Sabine

IPC: A61K38/46

CPC classification number: A61K38/46

Abstract: The invention relates to treatments for depressive disorders based on reducing the extracellular matrix in the hippocampus. The invention also relates to methods of screening for new compounds to treat depressive disorders.

Abstract translation: 本发明涉及基于减少海马体细胞外基质的抑郁症治疗。 本发明还涉及筛选新化合物以治疗抑郁障碍的方法。

公开(公告)号：WO2014065669A1

公开(公告)日：2014-05-01

申请号：PCT/NL2013/050756

申请日：2013-10-28

Applicant: STICHTING VU-VUMC

Inventor： SMIT, August Benjamin ,  VAN KESTEREN,, Ronald Ernst

IPC: A61K38/51 ,  A61P25/28

CPC classification number: A61K38/51

Abstract: The invention relates to treatments for cognitive decline and/or memory impairment based on reducing the extracellular matrix in the hippocampus. Improved compositions are provided for such treatments. The invention also relates to detection methods for the early diagnosis of cognitive decline and/or memory impairment based on an increase in extracellular matrix in the hippocampus. The treatments and diagnostic methods are especially useful in the field of Alzheimer's disease.

Abstract translation: 本发明涉及基于减少海马细胞外基质的认知衰退和/或记忆障碍的治疗。 为这些处理提供了改进的组合物。 本发明还涉及基于海马细胞外基质增加的认知衰退和/或记忆障碍的早期诊断的检测方法。 治疗和诊断方法在阿尔茨海默病领域特别有用。