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公开(公告)号：WO2015194956A1
公开(公告)日：2015-12-23
申请号：PCT/NL2015/050449
申请日：2015-06-19
Applicant: STICHTING VU-VUMC , INTERNA TECHNOLOGIES B.V.
Inventor： MEIJER, Gerrit Albert , DIOSDADO, Begoña , TIMMER, Lisette M. , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , CERISOLI, Francesco , SCHAAPVELD, Roeland Quirinus Jozef
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和装置以及生物标志物的用途。 描述的生物标志物在粪便中可靠地检测，并且与结肠直肠癌阴性患者相比，在结肠直肠癌患者中表现出显着不同的表达水平。
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公开(公告)号：EP3158083A1
公开(公告)日：2017-04-26
申请号：EP15738759.8
申请日：2015-06-19
Applicant: Stichting VU-VUmc , InteRNA Technologies B.V.
Inventor： MEIJER, Gerrit Albert , DIOSDADO, Begoña , TIMMER, Lisette M. , CUPPEN, Edwin Pieter Johan Gerard , BEREZIKOV, Eugene , CERISOLI, Francesco , SCHAAPVELD, Roeland Quirinus Jozef
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
Abstract translation: 公开了使用miRNA生物标志物诊断结肠直肠癌及其前体的方法，以及用于检测生物标志物的试剂盒和设备以及生物标志物的用途。 所描述的生物标志物在大便中可靠地检测到，并且与结肠直肠癌阴性患者相比在结肠直肠癌患者中表现出显着不同的表达水平。
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公开(公告)号：WO2013095132A1
公开(公告)日：2013-06-27
申请号：PCT/NL2012/050905
申请日：2012-12-20
Applicant: INTERNA TECHNOLOGIES B.V. , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Inventor： BRAKENHOFF, Rudolf Henrikus , VAN DER PLAS, Marlon , DE KEMP, Sanne Rosaly , GOMMANS, Willemijn Maria , PREVOST, Grégoire Pierre André , SCHAAPVELD, Roeland Quirinus Jozef , CERISOLI, Francesco
IPC: C12N15/113 , A61K31/713 , A61P35/00
CPC classification number: C12N15/113 , C12N2310/141 , C12N2320/31
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
Abstract translation: 本发明涉及miRNA-323，miRNA-342，miRNA-326，miRNA-371，miRNA-3157和/或miRNA-345分子的诊断和治疗用途，其在相关疾病和病症中的等同或来源 具有鳞状细胞癌如头颈部癌症或癌前变粘膜变化。
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公开(公告)号：EP2794881A1
公开(公告)日：2014-10-29
申请号：EP12819153.3
申请日：2012-12-20
Applicant: InteRNA Technologies B.V. , Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg
Inventor： BRAKENHOFF, Rudolf Henrikus , VAN DER PLAS, Marlon , DE KEMP, Sanne Rosaly , GOMMANS, Willemijn Maria , PREVOST, Grégoire Pierre André , SCHAAPVELD, Roeland Quirinus Jozef , CERISOLI, Francesco
IPC: C12N15/113 , A61K31/713 , A61P35/00
CPC classification number: C12N15/113 , C12N2310/141 , C12N2320/31
Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.
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