公开(公告)号：WO2022036174A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/045874

申请日：2021-08-13

Applicant: STRECK, INC.

Inventor： SALAMIFAR, Sean ,  GEORGE, Nick ,  HUNSLEY, Brad

IPC: B01L3/00 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/16 ,  B01L3/5082

Abstract: The present teachings relate to a method of making a biological sample collection container, an internally coated biological sample collection container, and uses of the same, particularly for omic analysis. A reagent (or a reagent precursor) is deposited in a liquid state at least partially along at least one side wall of the container. The reagent precursor is dried to form a dried coating having a predefined pattern and topology along at least a portion of the at least one side wall. A container thus results having a coating that includes, in a dried state, a stabilizer agent, or reaction product of a stabilizer agent and an anticoagulant, and upon collection of a sample enables stabilization of any present white blood cells, cell-free nucleic acids, extracellular vesicles, circulating tumor cells, proteins, metabolites, lipids, or any combination thereof, and preserving them in sufficient quantity and quality for omic analysis.