公开(公告)号：US20180140549A1

公开(公告)日：2018-05-24

申请号：US15580732

申请日：2016-06-08

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD

Inventor： Wen Wee MA ,  Alex ADJEI ,  Lynne BUI ,  Ronald HARNING ,  Ajay KHOPADE ,  Subhas BHOWMICK ,  Natarajan ARULSUDAR ,  Narendra LAKKAD

IPC: A61K9/10 ,  A61K31/337 ,  A61P35/00 ,  A61K9/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/32 ,  A61K47/28

CPC classification number: A61K9/10 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/337 ,  A61K47/10 ,  A61K47/12 ,  A61K47/28 ,  A61K47/32 ,  A61P35/00

Abstract: A method of treating patients suffering from carcinoma of intrahepatic or extra hepatic bile duct or gall bladder which is locally advanced or metastatic, by intravenously administering to the patient, paclitaxel in the form of a nanodispersion. The nanodispersion comprises particles with a mean particle size less than 300 nm and is free of polyoxyethylated castor oil and free of a protein.

公开(公告)号：US20140030352A1

公开(公告)日：2014-01-30

申请号：US14045250

申请日：2013-10-03

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Ajay Jaysingh KHOPADE ,  Subhas Balaram BHOWMICK ,  Natarajan ARULSUDAR

IPC: A61K9/10 ,  A61K9/08 ,  A61K9/14 ,  A61K31/337

CPC classification number: A61K9/10 ,  A61K9/08 ,  A61K9/1075 ,  A61K9/146 ,  A61K9/5138 ,  A61K9/5146 ,  A61K31/337

Abstract: The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said nanoparticles comprising one or more taxane derivative, a polymer and a surfactant comprising a mixture of fatty acids or its salts and sterol or its derivatives or its salts.

Abstract translation: 本发明提供纳米分散体，其包含分散在包含水混溶性溶剂和水的载体中的平均粒径小于300nm的纳米颗粒，所述纳米颗粒包含一种或多种紫杉烷衍生物，聚合物和包含脂肪酸或其混合物的混合物的表面活性剂 盐和甾醇或其衍生物或其盐。