公开(公告)号：US11813252B2

公开(公告)日：2023-11-14

申请号：US17747472

申请日：2022-05-18

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji Damle ,  Sanjay Nandlalji Mandhane ,  Manoj Atmaramji Upadhya ,  Sameer Vishwanath Mehetre ,  Gajanan Uttamrao Chidrewar ,  Prabal Sengupta ,  Trinadha Rao Chitturi

IPC: A61K31/44 ,  A61P25/16 ,  A61K31/47

CPC classification number: A61K31/44 ,  A61K31/47 ,  A61P25/16

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I






wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen;
or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl;
R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11583522B2

公开(公告)日：2023-02-21

申请号：US17061139

申请日：2020-10-01

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji Damle ,  Sanjay Nandlalji Mandhane ,  Manoj Atmaramji Upadhya ,  Sameer Vishwanath Mehetre ,  Gajanan Uttamrao Chidrewar ,  Prabal Sengupta ,  Trinadha Rao Chitturi

IPC: A61K31/44 ,  A61P25/16 ,  A61K31/47

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3 alkyl, C1-3 haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.

公开(公告)号：US10849887B2

公开(公告)日：2020-12-01

申请号：US16304914

申请日：2017-06-02

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Nitin Krishnaji Damle ,  Sanjay Nandlalji Mandhane ,  Manoj Atmaramji Upadhya ,  Sameer Vishwanath Mehetre ,  Gajanan Uttamrao Chidrewar ,  Prabal Sengupta ,  Trinadha Rao Chitturi

IPC: A61K31/44 ,  A61P25/16 ,  A61K31/47

Abstract: The invention relates to a method of treating or preventing Parkinson's disease in a subject comprising administering a compound of Formula I wherein, R1 is —NHC(O) C3-6 cycloalkyl and R2 is hydrogen; or R1 and R2 along with the carbon atoms to which they are attached form a six membered aromatic ring, wherein the ring is substituted with one or more groups selected from hydrogen, halogen and C1-6 alkyl; R3 and R4 are independently selected from group comprising hydrogen, halogen, C1-3 alkyl, OC1-3 alkyl, NO2, SC1-3, alkyl, C1-3, haloalkyl, OC1-3 haloalkyl, and SC1-3 haloalkyl; or a pharmaceutically acceptable salt thereof.