公开(公告)号：US10512608B2

公开(公告)日：2019-12-24

申请号：US15552966

申请日：2016-02-25

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： Madhusudhan Bommagani ,  Subhas Balaram Bhowmick ,  Prashant Kane ,  Vaibhav Dubey

IPC: A61K9/14 ,  A61K31/65 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61K9/12 ,  A61K47/14

Abstract: The present invention relates to a nanoparticulate topical composition comprising (i) nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm, (ii) one or more wetting agent and (iii) a non-aqueous liquid vehicle, wherein the composition is free of water.The present invention also relates to a method of treating acne, rosacea, impetigo or a skin disease caused by a bacteria, by topical application of a nanoparticulate topical composition comprising nanoparticles of a water soluble and water susceptible active ingredient or its pharmaceutically acceptable salt, having a particle size distribution such that 90% of the particles are less than 1000 nm.