公开(公告)号：WO2016120892A1

公开(公告)日：2016-08-04

申请号：PCT/IN2016/050032

申请日：2016-01-29

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.

Inventor： DHARMADIKARI, Nitin Bhalachandra ,  ZALA, Yashoraj R. ,  KHAN, Mohammed Majed

IPC: A61K9/20 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36

CPC classification number: A61K9/284 ,  A61K9/2031 ,  A61K9/2077 ,  A61K9/2081

Abstract: An abuse deterrent multiparticulate solid dosage form comprising: • a first composition comprising coated cores, each coated core comprising a. a core comprising a drug susceptible to abuse and a crush resistant carrier having a first melting point b. a first coat surrounding the said core and comprising water soluble polymer, c. a second coat surrounding the first coat and optionally, a third coat, surrounding the second coat, the second and/or third coat comprising a water insoluble polymer, d. an outermost coat surrounding the inner concentric coats and consisting essentially of a reverse enteric polymer, and • a second composition comprising an alkalizer.

Abstract translation: 一种滥用威慑多颗粒固体剂型，其包含：•包含涂覆核心的第一组合物，每个涂覆的核心包含a。 包括易于滥用的药物和具有第一熔点b的抗压载体的核心。 环绕所述芯并且包含水溶性聚合物的第一涂层，c。 围绕第一涂层的第二涂层和任选地围绕第二涂层的第三涂层，第二涂层和/或第三涂层包含水不溶性聚合物，d。 围绕所述内同心涂层并且基本上由反向肠溶性聚合物组成的最外涂层，和包含碱化剂的第二组合物。