公开(公告)号：NO931105D0

公开(公告)日：1993-03-25

申请号：NO931105

申请日：1993-03-25

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18 ,  C07D

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：NO179447C

公开(公告)日：1996-10-09

申请号：NO931105

申请日：1993-03-25

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：NO179447B

公开(公告)日：1996-07-01

申请号：NO931105

申请日：1993-03-25

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：FI102747B1

公开(公告)日：1999-02-15

申请号：FI931429

申请日：1993-03-30

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：AU669507B2

公开(公告)日：1996-06-13

申请号：AU3538693

申请日：1993-03-23

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：FI931429A

公开(公告)日：1993-10-01

申请号：FI931429

申请日：1993-03-30

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：DE69330658T2

公开(公告)日：2002-07-04

申请号：DE69330658

申请日：1993-03-30

Applicant: SUNTORY LTD OSAKA ,  NIPPON SODA CO

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：AT204860T

公开(公告)日：2001-09-15

申请号：AT93105239

申请日：1993-03-30

Applicant: SUNTORY LTD ,  NIPPON SODA CO

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：NO931105L

公开(公告)日：1993-10-01

申请号：NO931105

申请日：1993-03-25

Applicant: SUNTORY LTD

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18 ,  C07D205/08

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.

公开(公告)号：ES2161218T3

公开(公告)日：2001-12-01

申请号：ES93105239

申请日：1993-03-30

Applicant: SUNTORY LTD ,  NIPPON SODA CO

Inventor： NAKAJIMA MASASHI ,  KIMURA YASUHARU ,  IMAI KIYOHITO

IPC: C07D201/02 ,  C07D205/09 ,  C07D403/12 ,  C07D405/12 ,  C07F7/18

Abstract: A process for producing a 4-substituted azetidinone derivative represented by the following general formula [III]: (wherein OR is a protected hydroxy group, Y is an alkyl group, an alkoxy group, a silyloxy group, a carbamoyloxy group, an amino group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group, and n is an integer of 0 or 1, provided that n does not represent O when Y is an alkoxy group, silyloxy group, carbamoyloxy group or amino group), characterized in that a 2-azetidinone derivative represented by the following general formula [I]: (wherein OR is as defined above, and X is an alkyl group or a substituted or unsubstituted aromatic group) is reacted with thiocarboxylic acid represented by the following general formula [II]: HSCO-(CH2)n-Y [II] (wherein Y and n are respectively as defined above) in an organic solvent in the presence of copper compounds. The aforementioned method can shorten the production process compared with the prior method. It is also highly advantageous from an industrial point of view because it does not employ mercury salts.