公开(公告)号：WO2006107900A3

公开(公告)日：2006-10-12

申请号：PCT/US2006/012374

申请日：2006-03-31

Applicant: SYMYX TECHNOLOGIES, INC. ,  CYPES, Stephen ,  UHRICH, Mark ,  CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  PADOWITZ, David ,  BENNETT, James ,  MATSIEV, Leonid

Inventor： CYPES, Stephen ,  UHRICH, Mark ,  CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  PADOWITZ, David ,  BENNETT, James ,  MATSIEV, Leonid

IPC: G01N29/02 ,  G01N29/036 ,  G01N29/22 ,  G01N9/00 ,  G01N11/10 ,  G01N27/00

Abstract: Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as batch distillation operations or continuous distillation operations, are disclosed. Preferred embodiments are directed to process monitoring and/or process control for unit operations involving endpoint determination of a distillation, for example, as applied to a liquid-component-switching operation (e.g., a solvent switching operation), a liquid-liquid separation operation, a solute concentration operation, a dispersed-phase concentration operation, among others.

公开(公告)号：WO2004078131A2

公开(公告)日：2004-09-16

申请号：PCT/US2004/006327

申请日：2004-03-01

Applicant: SYMYX TECHNOLOGIES, INC. ,  CARLSON, Eric, D. ,  DESROSIERS, Peter, J. ,  SONG, Li

Inventor： CARLSON, Eric, D. ,  DESROSIERS, Peter, J. ,  SONG, Li

IPC: A61K

CPC classification number: G01N33/15 ,  B01J2219/00599 ,  B01J2219/00686 ,  B01J2219/00702 ,  B01J2219/00756 ,  C40B60/12

Abstract: The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.

Abstract translation: 本发明涉及药物制剂的研究领域。 更具体地，本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时，在多种药物组合物中进行平行合成和筛选以确保稳定性和相容性的装置和方法。 一方面，本发明包括测试病症对药物样品的影响的方法。 该方法包括提供药物样品阵列，同时将阵列内的第一组多个药物样品暴露于暴露期内的一段时间内的第一受控状态，以及第一次评估多个暴露的药物样品 并且第二次使用非破坏性测试来确定条件是否随着时间对一种或多种药物样品产生影响。 所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。

公开(公告)号：WO2003100390A3

公开(公告)日：2003-12-04

申请号：PCT/US2003/012503

申请日：2003-04-23

Applicant: SYMYX TECHNOLOGIES, INC. ,  CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  MATSIEV, Leonid ,  MAZZOLA, Laura, T. ,  SPITKOVSKY, Mikhail ,  GALLIPEO, John

Inventor： CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  MATSIEV, Leonid ,  MAZZOLA, Laura, T. ,  SPITKOVSKY, Mikhail ,  GALLIPEO, John

IPC: G01N5/04

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate a system (100) including one resonator, or a plurality of resonators in a resonator array (110), adapted to monitor the response of a sample to a change in environmental condition, and correlating the response with mass change in the samples.

公开(公告)号：WO2003039254A1

公开(公告)日：2003-05-15

申请号：PCT/EP2002/012401

申请日：2002-11-06

Applicant: BASF AKTIENGESELLSCHAFT ,  SYMYX TECHNOLOGIES INC. ,  KOLTZENBURG, Sebastian ,  SCHROF, Wolfgang ,  SEUFERT, Michael ,  HEGER, Robert ,  LEHMANN, Stephan ,  KARDORFF, Uwe ,  ZAGAR, Cyrill ,  BRATZ, Matthias ,  CARLSON, Eric, D. ,  CHANG, Han, Ting ,  KUEBLER, Sigrid, C.

Inventor： KOLTZENBURG, Sebastian ,  SCHROF, Wolfgang ,  SEUFERT, Michael ,  HEGER, Robert ,  LEHMANN, Stephan ,  KARDORFF, Uwe ,  ZAGAR, Cyrill ,  BRATZ, Matthias ,  CARLSON, Eric, D. ,  CHANG, Han, Ting ,  KUEBLER, Sigrid, C.

IPC: A01N37/46

CPC classification number: A01N25/10 ,  A01N37/32 ,  A01N37/46 ,  A01N25/12 ,  A01N25/04 ,  A01N2300/00 ,  A01N25/14

Abstract: The invention relates to a solid crop protection formulation comprising a) cinidon-ethyl as a crop protection agent; b) at least one random radical copolymer comprising as polymerized units at least one hydrophilic and at least one hydrophobic monomer; and c) optionally further additives, wherein at least 50 % of the dispersed cinidon-ethyl particles in said solid crop protection formulation are in an X-ray amorphous state and an aqueous dispersion formulation thereof. Additionally, the invention relates to processes for preparing said formulations and the use of said formulations in agriculture. Further, the invention relates to a random radical copolymer essentially consisting of as polymerized units a) 5 to 95 % by weight of styrene as component A; b) 5 to 95 % by weight of DMAPMAM (dimethylaminopropyl methacrylic amide) as component B; c) 0 to 98 % by weight of methyl acrylate and/or vinyl acetate as component C.

Abstract translation: 本发明涉及一种固体作物保护制剂，其包含作为作物保护剂的cinidon-ethyl b至少一种无规自由基共聚物，其包含作为聚合单元的至少一种亲水和至少一种疏水性单体和c任选的其它添加剂，其中至少50 所述固体作物保护制剂中分散的cinidon-ethyl颗粒的％为X射线无定形状态及其水分散体制剂。 此外，本发明涉及制备所述制剂的方法和所述制剂在农业中的用途。 此外，本发明涉及一种无规自由基共聚物，其基本上由作为聚合单元的组分为5至95重量％的苯乙烯作为组分A b 5至95重量％的DMAPMAM二甲基氨基丙基甲基丙烯酰胺作为组分B c 0至98重量％ 的丙烯酸甲酯和/或乙酸乙烯酯作为组分C.

公开(公告)号：WO2004000452A1

公开(公告)日：2003-12-31

申请号：PCT/US2003/015310

申请日：2003-05-15

Applicant: SYMYX TECHNOLOGIES, INC. ,  GIAQUINTA, Daniel, M. ,  CARLSON, Eric, D.

Inventor： GIAQUINTA, Daniel, M. ,  CARLSON, Eric, D.

IPC: B01J19/00

CPC classification number: G01N23/20 ,  Y10T436/24

Abstract: A method for characterization of a solid material sample, including the steps of providing a liquid medium for delivering a solid material sample to a porous substrate 18, preferably in discrete regions 32. Solid sample is separated from the liquid medium by filtering through the porous substrate. Analysis such as x-ray analysis of the solid sample is conducted while the sample resides on the porous substrate.

Abstract translation: 一种用于表征固体材料样品的方法，包括以下步骤：提供用于将固体材料样品输送到多孔基材18，优选在离散区域32中的液体介质。固体样品通过多孔基材过滤而与液体介质分离 。 当样品驻留在多孔基材上时，进行诸如固体样品的X射线分析的分析。

公开(公告)号：WO2003099909A1

公开(公告)日：2003-12-04

申请号：PCT/EP2002/007457

申请日：2002-05-23

Applicant: RHODIA CHIMIE ,  SYMYX TECHNOLOGIES, INC ,  BRUMMER, Oliver ,  CARLSON, Eric, D. ,  CREVIER, Thomas ,  GIRAUD, Yves ,  LA POINTE, Anne-Marie ,  STERIN, Sébastien

Inventor： BRUMMER, Oliver ,  CARLSON, Eric, D. ,  CREVIER, Thomas ,  GIRAUD, Yves ,  LA POINTE, Anne-Marie ,  STERIN, Sébastien

IPC: C08G77/08

CPC classification number: C08G77/08 ,  C07F15/0086 ,  C08G77/12 ,  C08G77/20 ,  C08L83/04 ,  C08L83/00

Abstract: This invention relates to silicone compositions which can be crosslinked, preferably into elastomers, by hydrosilylation of at least one PolyOrganoSiloxane -A- carrying unsaturated bonds, using at least one polyorganohydrosiloxane -B- in the presence of carbene-based metal catalyst -C- as defined in claim 1 and which optionally comprise at least one inhibitor -D- of the hydrosilylation reaction.

Abstract translation: 本发明涉及通过使用至少一种聚有机氢硅氧烷-B-在卡宾系金属催化剂-C-存在下，使至少一种携带不饱和键的至少一种聚有机硅氧烷-A-进行氢化硅烷化，优选进行弹性体的硅酮组合物 权利要求1中限定，并且其任选地包含氢化硅烷化反应的至少一种抑制剂-D-。

公开(公告)号：WO2003051996A1

公开(公告)日：2003-06-26

申请号：PCT/EP2001/015422

申请日：2001-12-19

Applicant: RHODIA CHIMIE ,  SYMYX TECHNOLOGIES, INC ,  LA POINTE, Anne-Marie ,  CARLSON, Eric, D. ,  CREVIER, Thomas ,  GIRAUD, Yves ,  STERIN, Sébastien

Inventor： CARLSON, Eric, D. ,  CREVIER, Thomas ,  GIRAUD, Yves ,  STERIN, Sébastien

IPC: C08L83/04

CPC classification number: C08K5/0091 ,  C08G77/08 ,  C08G77/12 ,  C08G77/20 ,  C08G77/24 ,  C08G77/70 ,  C08K5/3442 ,  C08L83/04 ,  C08L83/00 ,  C08L2666/52

Abstract: This invention relates to the use of an effective amount of a composition based on a palladium catalyst for preparing a polyaddition heat type curable polyorganosiloxane elastomer. It is also directed to a polyaddition heat type curable polyorganosiloxane elastomer.

Abstract translation: 本发明涉及有效量的基于钯催化剂的组合物用于制备加聚热固化型聚有机硅氧烷弹性体的用途。 它还涉及加聚热固化聚有机硅氧烷弹性体。

公开(公告)号：WO2003019150A1

公开(公告)日：2003-03-06

申请号：PCT/US2002/026112

申请日：2002-08-15

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： HAJDUK, Damian, A. ,  CARLSON, Eric, D. ,  FREITAG, J., Christopher ,  KOLOSOV, Oleg ,  ENGSTROM, James, R. ,  SAFIR, Adam ,  SRINIVASAN, Ravi ,  MATSIEV, Leonid

IPC: G01N3/10

CPC classification number: B82Y30/00 ,  B01J2219/00274 ,  B01J2219/00315 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00707 ,  B01J2219/00716 ,  B01J2219/00722 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/14 ,  G01N3/10 ,  G01N3/18 ,  G01N2203/0016 ,  G01N2203/0252 ,  G01N2203/0254 ,  G01N2203/0258 ,  G01N2203/0617 ,  G01N2203/0623 ,  G01N2203/0641

Abstract: A method for high throughput mechanical property testing of materials libraries. A suitable system, such as an automated system 1 0, is provided. A plurality of samples on a substrate are monito red for their response to a force directed by a Force Application source (FAS) 18, where the force applied is selected from thegroup consisting of a fluid, a voltage, a piezoelectric, and a combination thereof.

Abstract translation: 一种材料库高通量力学性能测试方法。 提供了适合的系统，例如自动化系统10。 衬底上的多个样品对于由力施加源（FAS）18引导的力的响应是红色的，其中所施加的力选自流体，电压，压电和组合 它们。

公开(公告)号：WO2003014732A1

公开(公告)日：2003-02-20

申请号：PCT/US2002/016962

申请日：2002-05-24

Applicant: SYMYX TECHNOLOGIES, INC. ,  CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

Inventor： CARLSON, Eric, D. ,  CONG, Peijun ,  CHANDLER, William, H., Jr. ,  CHAU, Henry, K. ,  DANIELSON, Earl ,  DESROSIERS, Peter, J. ,  DOOLAN, Robert, D. ,  WU, Luping

IPC: G01N33/48

CPC classification number: B01L3/50255 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00364 ,  B01J2219/00373 ,  B01J2219/00423 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00725 ,  B01J2219/00756 ,  B01L3/06 ,  B01L7/00 ,  B01L2300/0829 ,  B01L2300/185 ,  C40B40/04 ,  C40B40/10 ,  C40B60/10 ,  C40B60/14 ,  G01N5/045 ,  G01N21/23 ,  G01N21/65 ,  G01N25/04 ,  G01N33/15 ,  G01N33/54366 ,  G01N35/028 ,  G01N2013/006 ,  G01N2021/651 ,  G01N2500/00 ,  G06F19/703 ,  G06F19/709 ,  Y10T117/10

Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymporphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system.

Abstract translation: 本发明提供了用于进行候选药物的盐和多形态的高通量制备和筛选的方法，装置和系统。 本发明旨在增强用于药物开发的预配制发现过程。 特别地，提供了确定基本上发现可以从特定药物候选物形成的每个多晶型物的合适的盐和方法的方法。 使用特定配置为在高吞吐量表征过程中执行各种步骤的几个装置来执行处理。 一种这样的装置被配置为基于例如由计算机系统生成的库模型来合成多个库成员。

公开(公告)号：WO2003100390A2

公开(公告)日：2003-12-04

申请号：PCT/US2003/012503

申请日：2003-04-23

Applicant: SYMYX TECHNOLOGIES, INC. ,  CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  MATSIEV, Leonid ,  MAZZOLA, Laura, T. ,  SPITKOVSKY, Mikhail ,  GALLIPEO, John

Inventor： CARLSON, Eric, D. ,  KOLOSOV, Oleg ,  MATSIEV, Leonid ,  MAZZOLA, Laura, T. ,  SPITKOVSKY, Mikhail ,  GALLIPEO, John

IPC: G01N19/00

CPC classification number: G01N29/036 ,  B01J2219/00689 ,  B01J2219/00707 ,  G01G3/13 ,  G01N5/045 ,  G01N33/15 ,  G01N2291/0257

Abstract: A method and apparatus for measurement of mass of small sample sizes. The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program. The method and apparatus contemplate a system (100) including one resonator, or a plurality of resonators in a resonator array (110), adapted to monitor the response of a sample to a change in environmental condition, and correlating the response with mass change in the samples.

Abstract translation: 用于测量小样品量的质量的方法和装置。 该方法和装置特别适于提供固体材料的微量天平测量作为组合研究程序的一部分。 该方法和装置考虑了包括谐振器阵列（110）中的一个谐振器或多个谐振器的系统（100），其适于监测样品对环境条件变化的响应，并且将响应与质量变化相关联 样品。