公开(公告)号：US20030100119A1

公开(公告)日：2003-05-29

申请号：US10269362

申请日：2002-10-11

Applicant: Symyx Technologies, Inc.

Inventor： W. Henry Weinberg ,  Eric McFarland ,  Isy Goldwasser ,  Thomas Boussie ,  Howard Turner ,  Johannes A.M. Van Beek ,  Vince Murphy ,  Tim Powers

IPC: G01N001/10

CPC classification number: G01N29/348 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/0075 ,  B01J2219/00754 ,  C07F15/0066 ,  C07F15/045 ,  C08F10/00 ,  C08F110/02 ,  C40B40/18 ,  C40B60/14 ,  G01N29/0681 ,  G01N29/2418 ,  G01N2291/106 ,  Y10T436/2575 ,  C08F4/7006 ,  C08F4/027 ,  C08F2500/03 ,  C08F4/7081

Abstract: The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

Abstract translation: 本发明尤其涉及有机金属化合物和催化剂（例如均相催化剂）的合成，筛选和表征的方法。 本发明的方法提供了负载和未负载的有机金属化合物和催化剂（例如均相催化剂）的文库的组合合成，筛选和表征。 本发明的方法可用于大量有机金属化合物的制备和筛选，所述有机金属化合物不仅可用作催化剂（例如均相催化剂），而且可用作添加剂和治疗剂。

公开(公告)号：US20030045000A1

公开(公告)日：2003-03-06

申请号：US10187406

申请日：2002-06-28

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Trevor G. Frank ,  Keith A. Hall ,  William H. Chandler JR. ,  Thomas Boussie ,  Thomas J. Crevier ,  Leonid Matsiev ,  Christopher Goh

IPC: G01N001/10

CPC classification number: G01N31/10 ,  B01J19/0046 ,  G01N25/72 ,  G01N35/025 ,  G01N2035/00188 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/25

Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber is disclosed. The apparatus includes a reaction chamber for receiving one or more libraries, each of the libraries comprising two or more samples. The reaction chamber is configured to form a sealed enclosure. The apparatus further includes an injection manifold supporting injectors for in-situ injection of one or more chemical components onto respective samples of the one or more libraries in the pressurized sealed reaction chamber.

Abstract translation: 公开了一种用于将一种或多种化学成分原位注入反应室的装置。 该装置包括用于接收一个或多个库的反应室，每个库包括两个或更多个样品。 反应室被配置成形成密封的外壳。 该装置还包括支撑注射器的注射歧管，用于将一个或多个化学组分原位注射到加压密封反应室中的一个或多个文库的相应样品上。

公开(公告)号：US20040175760A1

公开(公告)日：2004-09-09

申请号：US10803115

申请日：2004-03-16

Applicant: Symyx Technologies, Inc.

Inventor： Thomas Crevier ,  William B. Archibald ,  Marc Hornbostel ,  Dieter Schaefer ,  Thomas Boussie

IPC: G01N033/53 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

CPC classification number: G01N35/085 ,  B01J19/0046 ,  B01J19/26 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00452 ,  B01J2219/00495 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  G01J4/00 ,  G01N15/0205 ,  G01N21/253 ,  G01N21/64 ,  G01N29/036 ,  G01N29/2425 ,  G01N29/348 ,  G01N29/4427 ,  G01N33/44 ,  G01N2015/0288 ,  G01N2015/0294 ,  G01N2291/106 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/115831

Abstract: Computer programs and computer-implemented methods implement techniques for evaluating experimental data from a library of materials. The techniques receive a plurality of images of a library of materials that includes an array of members associated with locations in the library. User input identifying a plurality of regions of interest is received. A series of reduced data values is determined for one or more of the regions of interest as a statistical function of a plurality of pixel values for pixels in the corresponding regions. A figure of merit is calculated from one or more of the series of reduced data values for a library member at the corresponding library location. The regions of interest include a plurality of pixels in the images and correspond to locations in the library.

Abstract translation: 计算机程序和计算机实现的方法实施用于从材料库评估实验数据的技术。 这些技术接收包括与库中的位置相关联的成员阵列的材料库的多个图像。 接收识别感兴趣区域的用户输入。 为一个或多个感兴趣区域确定一系列缩减数据值作为对应区域中的像素的多个像素值的统计函数。 从相应库位置的库成员的一系列缩减数据值中计算一个品质因数。 感兴趣的区域包括图像中的多个像素并且对应于库中的位置。

公开(公告)号：US20030003017A1

公开(公告)日：2003-01-02

申请号：US09895945

申请日：2001-06-29

Applicant: Symyx Technologies, Inc.

Inventor： Trevor G. Frank ,  Keith A. Hall ,  William H. Chandler JR. ,  Thomas Boussie ,  Thomas J. Crevier ,  Leonid F. Matsiev

IPC: G01N015/00

CPC classification number: G01N31/10 ,  B01J19/0046 ,  G01N25/72 ,  G01N35/025 ,  G01N2035/00188 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/25

Abstract: An apparatus for in-situ injection of one or more chemical components into a reaction chamber, comprising a reaction chamber for receiving one or more libraries including two or more samples; an injection module in fluid communication with the reaction chamber for permitting in-situ injection of one or more chemical components into the reaction chamber; and a selectively movable transport assembly supported by at least a portion of the reaction chamber for transporting the one or more libraries to the injection module.

Abstract translation: 一种用于将一种或多种化学组分原位注入反应室的装置，包括用于接收一个或多个包含两个或更多个样品的文库的反应室; 与所述反应室流体连通的注射模块，用于允许将一种或多种化学组分原位注射到所述反应室中; 以及由所述反应室的至少一部分支撑的用于将所述一个或多个库传送到所述注射模块的选择性移动的运输组件。