公开(公告)号：CA2344755A1

公开(公告)日：2001-11-26

申请号：CA2344755

申请日：2001-04-18

Applicant: SYMYX TECHNOLOGIES INC

Inventor： CARLSON ERIC ,  FREITAG J CHRISTOPHER ,  HAJDUK DAMIAN ,  KOSOLOV OLEG

IPC: G01N11/00 ,  B01L3/00 ,  G01N1/28 ,  G01N3/02 ,  G01N3/08 ,  G01N3/20 ,  G01N3/32 ,  G01N5/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/22 ,  G01N37/00 ,  G01N3/00

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing t he library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members t o the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen librarie s of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, meltflow indexing, and rheology), among others.

公开(公告)号：CA2344755C

公开(公告)日：2004-11-09

申请号：CA2344755

申请日：2001-04-18

Applicant: SYMYX TECHNOLOGIES INC

Inventor： KOSOLOV OLEG ,  CARLSON ERIC ,  HAJDUK DAMIAN ,  FREITAG J CHRISTOPHER

IPC: G01N11/00 ,  B01L3/00 ,  G01N1/28 ,  G01N3/02 ,  G01N3/08 ,  G01N3/20 ,  G01N3/32 ,  G01N5/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/22 ,  G01N37/00 ,  G01N3/00

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing t he library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members t o the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen librarie s of materials based on, many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.