公开(公告)号：US20040087660A1

公开(公告)日：2004-05-06

申请号：US10643941

申请日：2003-08-20

Applicant: Sepracor Inc.

Inventor： Chris Hugh Senanayake ,  Zhengxu Han ,  Dhileepkumar Krishnamurthy ,  Derek Pflum

IPC: A61K031/137

CPC classification number: C07C209/60 ,  C07C313/06 ,  C07C2601/04 ,  C07C211/29

Abstract: This invention encompasses novel methods of preparing sibutramine and sibutramine derivatives, and stereomerically pure sibutramine derivatives in particular. Examples of sibutramine derivatives include, but are not limited to, sibutramine metabolites such as desmethylsibutramine and didesmethylsibutramine. The invention further encompasses novel compounds useful in the synthesis of sibutramine derivatives.

Abstract translation: 本发明包括制备西布曲明和西布曲明衍生物的新方法，特别是立体异构纯的西布曲明衍生物。 西布曲明衍生物的实例包括但不限于西布曲明代谢物如脱甲基西布曲明和二甲基西布曲明。 本发明还包括可用于合成西布曲明衍生物的新化合物。