公开(公告)号：US20220325289A1

公开(公告)日：2022-10-13

申请号：US17825784

申请日：2022-05-26

Applicant: Sinai Health System

Inventor： Andras NAGY ,  Claudio MONETTI ,  Qin LIANG

IPC: C12N15/65 ,  C12N15/85 ,  C12N15/90 ,  C12N5/0735 ,  C12N5/10 ,  A61K48/00 ,  C12N15/63

Abstract: The present disclosure provides molecular tools, methods and kits for using cell division loci (CDLs) to control cell proliferation in animal cells. CDLs, as provided herein, are loci whose transcription product(s) are expressed during cell division. CDLs may be genetically modified, as described herein, to comprise a negative selectable marker and/or an inducible activator-based gene expression system, which allows a user to permit, ablate, and/or inhibit proliferation of the genetically modified cell(s) by adding or removing an appropriate inducer.

公开(公告)号：US20180044686A1

公开(公告)日：2018-02-15

申请号：US15556146

申请日：2016-03-09

Applicant: Sinai Health System

Inventor： Andras NAGY ,  Claudio MONETTI ,  Qin LIANG

IPC: C12N15/65 ,  C12N15/90 ,  C12N15/85

CPC classification number: C12N15/65 ,  C12N5/0606 ,  C12N5/10 ,  C12N15/85 ,  C12N15/907

Abstract: The present disclosure provides molecular tools, methods and kits for using cell division loci (CDLs) to control cell proliferation in animal cells. CDLs, as provided herein, are loci whose transcription product(s) are expressed during cell division. CDLs may be genetically modified, as described herein, to comprise a negative selectable marker and/or an inducible activator-based gene expression system, which allows a user to permit, ablate, and/or inhibit proliferation of the genetically modified cell(s) by adding or removing an appropriate inducer.