公开(公告)号：US10328123B2

公开(公告)日：2019-06-25

申请号：US15659570

申请日：2017-07-25

Applicant: St. Louis University

Inventor： Rajeev Aurora ,  Anna Smith ,  Angel Baldan

IPC: A61K38/17

Abstract: Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

公开(公告)号：US20180085431A1

公开(公告)日：2018-03-29

申请号：US15659570

申请日：2017-07-25

Applicant: St. Louis University

Inventor： Rajeev Aurora ,  Anna Smith ,  Angel Baldan

IPC: A61K38/17

CPC classification number: A61K38/177 ,  A61K38/1709

Abstract: Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (TcREG). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (TcREG) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.