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    6-Aminouracil derivatives
    2.
    发明授权
    6-Aminouracil derivatives 失效
    6-氨基尿嘧啶衍生物

    公开(公告)号：US3923807A

    公开(公告)日：1975-12-02

    申请号：US39544873

    申请日：1973-09-10

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： FURUKAWA YOSHIYASU ,  SUNO MASAHIRO ,  NOSE SAWAMI

    IPC: C07D239/54 ,  C07D239/06

    CPC classification number: C07D239/54 ,  Y10S514/822 ,  Y10S514/869

    Abstract: Novel 6-aminouracil derivatives of the formula

    WHEREIN R1 is lower alkyl which may be substituted with hydroxy or lower alkoxy, R2 is halogen, nitro or lower alkyl and n is 0, 1 or 2, show a strong inhibitory action against adenosine -3'', 5'' cyclic phosphate phosphodiesterase in vitro, and exhibit excellent pharmacological actions such as diuretic, platelet aggregation inhibitory and broncho-dilating actions.

    D R A W I N G

    Abstract translation: 新颖的式6-氨基尿嘧啶衍生物，其中，R 1为可被羟基或低级烷氧基取代的低级烷基，R 2为卤素，硝基或低级烷基，n为0,1或2，对腺苷-3' 5'环磷酸二酯酶，体外表现出优异的药理作用，如利尿，血小板聚集抑制和支气管扩张作用。

    Method for production of cytidine (or deoxycytidine)-5{40 -diphosphate choline and intermediates therefor
    3.
    发明授权
    Method for production of cytidine (or deoxycytidine)-5{40 -diphosphate choline and intermediates therefor 失效
    生产CYDDINE（或脱氧胆酸）-5 {40-磷酸酯和其中间体的方法

    公开(公告)号：US3666748A

    公开(公告)日：1972-05-30

    申请号：US3666748D

    申请日：1968-12-17

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： HONJO MIKIO ,  FURUKAWA YOSHIYASU

    IPC: C07F9/24 ,  C07H19/10

    CPC classification number: C07H19/10 ,  C07F9/24

    Abstract: Cytidine-5''-diphosphate choline and deoxycytidine-5''-diphosphate choline are produced by reacting cytidine (or deoxycytidine)-5''monophosphate with a choline phosphoramidate. Choline phosphoramidates of the formula WHEREIN R1 and R2 represent hydrogen, a hydrocarbon residue having at most seven carbon atoms, or R1 and R2 taken together represent a five- or six-membered heterocyclic ring are prepared by reacting phosphorylcholine with an amine.

    Abstract translation: 胞苷-5'-二磷酸胆碱和脱氧胞苷-5'-二磷酸胆碱通过胞苷（或脱氧胞苷）-5'-单磷酸与氨基磷酸胆碱反应产生。 式WHEREIN R1和R2代表氢，具有至多7个碳原子的烃残基或R1和R2一起代表五元或六元杂环的胆碱磷酸亚氨基酯是通过使磷酰胆碱与胺反应来制备的。

    6.
    发明专利
    未知

    公开(公告)号：NO871024D0

    公开(公告)日：1987-03-12

    申请号：NO871024

    申请日：1987-03-12

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： NAKA TAKEHIKO ,  FURUKAWA YOSHIYASU ,  NAGAOKA AKINOBU

    IPC: A61K31/505 ,  C07D487/04 ,  A61P25/28 ,  C07D487/00

    Abstract: Novel pyrazola[3,4-d]pyrimidine derivatives represented by the formula (I)whereinRls an aryl or heteroaryl group which may be substituted;Ris a lower alkyl group;R 3 and R 4 are independently hydrogen or a lower alkyl group;R 5 is hydrogen, a lower alkyl group or a lower acyl group, the group R 5 being attached at the 1- or 2- position of the pyrazole ring;Xis a lower alkylene group which may contain a hetero-atom;and the dotted line designates the presence of two double bonds in the pyrazole ring and their salts activate cerebral functions and metabolisms.

    8.
    发明专利
    未知

    公开(公告)号：DK90083A

    公开(公告)日：1983-09-09

    申请号：DK90083

    申请日：1983-02-25

    Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

    Inventor： FURUKAWA YOSHIYASU

    IPC: A61K31/505 ,  A61P25/04 ,  A61P29/00 ,  C07D498/04 ,  C07D521/00 ,  C07D

    Abstract: Isoxazolo(3,4-d)pyrimidines of the formula … … wherein R and R , respectively, are lower alkyl; R is lower alkyl or acyl; and R is hydrogen, lower alkyl, or acyl have antiinflammatory, analgesic and antipyretic activities in mammals and low acute and subacute toxicities, as well. The compounds are particularly useful as an antiinflammatory, analgesic and antipyretic drug.

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