公开(公告)号：KR800001265B1

公开(公告)日：1980-10-26

申请号：KR760001116

申请日：1976-05-04

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： SHIRAISHI MITSURU ,  TSUSHIMA SUSUMU ,  MATSUMOTO NORICHIKA ,  SENDAI MICHIYUKI

IPC: A61K31/545 ,  C07D501/20

Abstract: Cephalosporins (I; R1 = H, acy1; R2 = residue group of nucleophilic compd.; X = carbony1 or sulfony1 substituted C2-3 branch; Z = residue group of organic acid), useful as bactericides, were prepd. by reacting compd.(II) with nucleophilic compd. Thus, 7β-(D-5-phthalimido-5-carboxyvaleramido)-3-[2-(carboethoxycarbamoy1)benzoy1 oxymethy1-3-cephem-4-carboxylic acid was suspended and then 5-mercapto-1-methy1-1H-tetrazole was added to give 7β-(D-5-phthalimido-5-carboxy-valeramide)-3-(1-methy1-1H-tetrazole-5-y1)thiomethy1-3-cephem-4-carboxylic acid.

公开(公告)号：US3919207A

公开(公告)日：1975-11-11

申请号：US28834372

申请日：1972-09-12

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TERAO SHINJI ,  MATSUO TAISUKE ,  TSUSHIMA SUSUMU ,  MIYAWAKI TOSHIO ,  MATSUMOTO NORICHIKA

IPC: A61K31/545 ,  C07D501/02 ,  C07D501/04 ,  C07D501/18

Abstract: The present invention relates to novel intermediates and a process for producing a compound of formula:

Abstract translation: 本发明涉及新的中间体及其制备方法，其中R4是被一个或两个苯基，环己烯基，噻吩基，吡啶硫基，氨基或磺基取代的乙酰基，其中氨基被未被保护或用盐酸保护 酸，异冰片氧基羰基，β-甲基磺酰基乙氧基羰基，苯甲酰基或硝基苯甲酰基，A表示式WHEREIN X为氢或乙酰氧基，R5为β-甲基磺酰基，三甲基甲硅烷基，甲氧基甲基或对硝基苄基的头孢菌素部分， 式：R1-C = NA | SR2其中R1是苄基或苯氧基甲基，R2是烷基，A具有与上述相同的含义，与下式的化合物R6-W其中R6是如上定义的乙酰基，W是 氯化物，溴化物，SO 3，NO 3或对甲苯磺酰基，在pH低于8.0的溶剂中。

公开(公告)号：DK0382380T3

公开(公告)日：1994-01-10

申请号：DK90300837

申请日：1990-01-26

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  NISHIKAWA KOHEI

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/47 ,  A61P7/02 ,  A61P9/00 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07D401/12

Abstract: Novel compound of the formula: is useful as a platelet activating factor antagonist and is so stable that it is advantageously used as drugs.

公开(公告)号：FI89907C

公开(公告)日：1993-12-10

申请号：FI880525

申请日：1988-02-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  HIRATA MINORU

IPC: C07C271/10 ,  A61K20060101 ,  A61K31/27 ,  A61K31/325 ,  A61K31/335 ,  A61K31/395 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61P9/06 ,  C07C20060101 ,  C07C269/02 ,  C07C271/06 ,  C07C271/12 ,  C07C271/24 ,  C07C271/28 ,  C07C275/00 ,  C07C275/14 ,  C07C275/28 ,  C07C323/25 ,  C07C333/04 ,  C07C333/06 ,  C07C333/10 ,  C07D209/48 ,  C07D211/04 ,  C07D211/34 ,  C07D211/58 ,  C07D213/24 ,  C07D213/36 ,  C07D213/38 ,  C07D213/53 ,  C07D295/10 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D521/00 ,  C07C333/02

公开(公告)号：PT86711B

公开(公告)日：1993-01-29

申请号：PT8671188

申请日：1988-02-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  HIRATA MIMORU

IPC: A61K31/27 ,  A61K31/325 ,  C07C271/08 ,  C07C333/04

公开(公告)号：NO167734B

公开(公告)日：1991-08-26

申请号：NO880511

申请日：1988-02-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  HIRATA MINORU

IPC: C07C271/10 ,  A61K20060101 ,  A61K31/27 ,  A61K31/325 ,  A61K31/335 ,  A61K31/395 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61P9/06 ,  C07C20060101 ,  C07C269/02 ,  C07C271/06 ,  C07C271/12 ,  C07C271/24 ,  C07C271/28 ,  C07C275/00 ,  C07C275/14 ,  C07C275/28 ,  C07C323/25 ,  C07C333/04 ,  C07C333/06 ,  C07C333/10 ,  C07D209/48 ,  C07D211/04 ,  C07D211/34 ,  C07D211/58 ,  C07D213/24 ,  C07D213/36 ,  C07D213/38 ,  C07D213/53 ,  C07D295/10 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D521/00

公开(公告)号：DK160313C

公开(公告)日：1991-07-29

申请号：DK63990

申请日：1990-03-12

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  SENDAI MICHIYUKI ,  SHIRAISHI MITSURU

IPC: A61K9/02 ,  A61K31/43 ,  C07D501/04 ,  C07D501/16 ,  C07D501/18 ,  C07D501/26

Abstract: Novel 3-acyloxymethyl-cephem compounds of the formula: wherein R1 is hydrogen or an acyl group; W is acetonyl, or a group represented by -X-COOH or -X-OH (X is an organic residue) or salts thereof were found to be useful as starting materials for preparing cephalosporins of the formula: wherein R3 stands for a residue of a nucleophilic compound and R1 has the same meaning as above.

公开(公告)号：AT44747T

公开(公告)日：1989-08-15

申请号：AT84306876

申请日：1984-10-09

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NOJIMA SHOSHICHI ,  NOMURA HIROAKI ,  TSUSHIMA SUSUMU

IPC: A01N57/10 ,  A01N57/12 ,  A01N57/16 ,  A61K31/685 ,  A61P35/00 ,  C07C43/13 ,  C07C43/164 ,  C07F9/10 ,  C07F9/58 ,  C07F9/6539

Abstract: Novel phospholipids, inclusive of salts thereof, of the formulawhereinR 1 and R 2 are independently an aliphatic hydrocarbon residue containing 1 to 20 carbon atoms, with the numbers of the carbon atoms for both totalling 8 to 30, andR 3 , R 4 and R 5 are independently hydrogen or C 1-6 alkyl, orrepresents a cyclic ammonio group, exhibitory activity against the multiplication of tumor cells and antifungal activity.

公开(公告)号：AU2010188A

公开(公告)日：1989-02-09

申请号：AU2010188

申请日：1988-07-27

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  NISHIKAWA KOHEI

IPC: C07D215/36 ,  A61K31/44 ,  A61K31/4425 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/495 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P43/00 ,  C07D213/71 ,  C07D213/79 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D215/48 ,  C07D215/54 ,  C07D401/12 ,  C07D405/12

Abstract: Novel pyridinium derivatives represented by the forumula (I): defined as in claim 1. The compounds are useful as antagonists of the platelet activating factor (PAF).

公开(公告)号：CA1248535A

公开(公告)日：1989-01-10

申请号：CA465026

申请日：1984-10-10

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NOJIMA SHOSHICHI ,  NOMURA HIROAKI ,  TSUSHIMA SUSUMU

IPC: A01N57/10 ,  A01N57/12 ,  A01N57/16 ,  A61K31/685 ,  A61P35/00 ,  C07C43/13 ,  C07C43/164 ,  C07F9/10 ,  C07F9/58 ,  C07F9/6539 ,  C07F9/09 ,  C07F9/65

Abstract: s of the Disclosure Novel phospholipids, inclusive of salts thereof, of the formula wherein R1 and R2 are independently an aliphatic hydrocarbon residue containing 1 to 20 carbon atoms, with the numbers of the carbon atoms for both totalling 8 to 30, and R3, R4 and R5 are independently hydrogen or C1-6 alkyl, or represents a cyclic ammonio group, exhibit inhibitory activity against multiplication or tumor cells and antifungal activity.