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公开(公告)号：KR810000860B1
公开(公告)日：1981-08-10
申请号：KR770000897
申请日：1977-04-14
Applicant: TAKEDA PHARMACEUTICAL
Inventor： MORINOTO AKIRA , OCHIAI MICHIHIKO , MATSUSIDA YOSHIHIRO
IPC: C07D501/36
Abstract: Title compds. (I; R3 = H or nucleophilic residue; R2NH = NH2-protecting group) were prepd. by the reaction of II and III. Thus, 290 mg 7-amino-3-(N-chloroacetyl)carbamoyloxymethyl-3-cephem-4-carboxylic acid and 276 mg 2-(2-chloroacetamidothiazol-4-yl)-2-(syn)-methoxyiminoacetylchloride were reacted for 15 min with ice-cooling and for 2 hr at room temp. to give 402 mg 7-2-(2-chloroacetamidothiazol-4-yl)-2-(syn)-methoxymethyl-3-cephem-4-carboxylic acid.
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