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公开(公告)号：KR810000493B1
公开(公告)日：1981-05-20
申请号：KR760000698
申请日：1976-03-23
Applicant: TAKEDA PHARMACEUTICAL
Inventor： SENDAI MIZZIUKI , TSUSIMA SUSMU , SIRAISI MISURU
IPC: C07D501/24
Abstract: A cephalosporin deriv. (I; R1 = H or acyl; R2 = residue of nucleophilic compd.) was prepd. by reaction of cephalosporanic acid ester (II; X = C6H5CH:, C6H4, CH3-CH-, -CH2CH2-) with nuclophilic compd. Formula II was obtained by acylation of 3-hydroxymethyl cephalosporanic acid with o-carboxymaleic anhydride or o-carboxysalicylic acid anhydride.
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