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公开(公告)号：KR830001415B1
公开(公告)日：1983-07-25
申请号：KR770001971
申请日：1977-08-24
Applicant: TAKEDA PHARMACEUTICAL
Inventor： NAITO KENJO , TSUGAMURA KAZUO , SHINPO HARUO
IPC: C07D501/36
Abstract: The solid, storage stable cephalosporin salts I(X=Cl,Br; n=0-6) were prepd. by treating H2NCH2CH2NMe2 with CS2, conveting Me2NCH2CH2NHCS2H to its Me ester, and cyclizing the latter with NaN3 to the tetrazolethiol II. Reaction of the acetoxymethylcephem III with II, followed by treatment with 12N HCl gave 94% pure I(X=Cl, n=1). The MIC of stepilococus aureus FDA 209p and toxicity of mice were 0.39mcg/ml and CD 50>=20 g/kg, resp.
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