公开(公告)号：WO2020130152A1

公开(公告)日：2020-06-25

申请号：PCT/JP2019/050228

申请日：2019-12-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： EDGINGTON-MITCHELL, Laura ,  MOUNTFORD, Simon ,  ANDERSON, Bethany M. ,  SZABO, Monika ,  AURELIO, Luigi ,  THOMPSON, Philip

IPC: C09B23/08 ,  C07C381/00 ,  C07D221/18 ,  G01N33/58 ,  A61K49/00

Abstract: The present invention relates to compounds of formula I bearing a sulfoxonium ylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.

公开(公告)号：WO2020130151A1

公开(公告)日：2020-06-25

申请号：PCT/JP2019/050223

申请日：2019-12-20

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： EDGINGTON-MITCHELL, Laura ,  ANDERSON, Bethany M. ,  POOLE, Daniel P. ,  AURELIO, Luigi ,  KASPERKIEWICZ, Paulina ,  DRAG, Marcin ,  BUNNETT, Nigel

IPC: C12Q1/37 ,  G01N33/573

Abstract: The present invention relates to compounds of formula I, wherein D is a detectable moiety, or salts thereof, which can be used as activity-based probes for neutrophil elastase, as well as to methods for detecting neutrophil elastase (NE) activity in a tissue sample lysate, and related diagnostic methods using compounds of formula I.

公开(公告)号：EP3898843A1

公开(公告)日：2021-10-27

申请号：EP19835852.5

申请日：2019-12-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： EDGINGTON-MITCHELL, Laura ,  MOUNTFORD, Simon ,  ANDERSON, Bethany M. ,  SZABO, Monika ,  AURELIO, Luigi ,  THOMPSON, Philip

IPC: C09B23/08 ,  C07C381/00 ,  C07D221/18 ,  G01N33/58 ,  A61K49/00

公开(公告)号：EP3899013A1

公开(公告)日：2021-10-27

申请号：EP19836846.6

申请日：2019-12-20

Applicant: Takeda Pharmaceutical Company Limited

Inventor： EDGINGTON-MITCHELL, Laura ,  ANDERSON, Bethany M. ,  POOLE, Daniel P. ,  AURELIO, Luigi ,  KASPERKIEWICZ, Paulina ,  DRAG, Marcin ,  BUNNETT, Nigel

IPC: C12Q1/37 ,  G01N33/573