公开(公告)号：WO2022229820A1

公开(公告)日：2022-11-03

申请号：PCT/IB2022/053829

申请日：2022-04-25

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YAMADA, Masatoshi ,  HIRANO, Sayuri ,  YABE, Osamu ,  KAJITA, Yuichi ,  ODA, Tsuneo ,  ABE, Takashi ,  YAMASHITA, Hironori

IPC: C07D207/14 ,  C07D207/22

Abstract: The present invention provides a method suitable for industrial production of a compound of formula (V): (V) comprising a step of subjecting a compound (IV) to an asymmetric reductive amination reaction in the presence of a metal complex comprising a chiral ligand and subjecting this product to purification using salt formation with N-(4-methylbenzene-1-sulfonyl)-L- phenylalanine. (IV)

公开(公告)号：WO2018100558A2

公开(公告)日：2018-06-07

申请号：PCT/IB2017/057588

申请日：2017-12-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YOSHIKAWA, Masato ,  SAITOH, Morihisa ,  KATO, Taisuke ,  YOSHITOMI, Yayoi ,  SEKI, Tomohiro ,  NAKAGAWA, Yasuo ,  TOMINARI, Yusuke ,  SETO, Masaki ,  SASAKI, Yusuke ,  OKANIWA, Masanori ,  ODA, Tsuneo ,  SHIBUYA, Akito ,  HIDAKA, Kosuke ,  SHIOKAWA, Zenyu ,  MURATA, Shumpei ,  OKABE, Atsutoshi ,  NAKADA, Yoshihisa ,  MOCHIZUKI, Michiyo ,  FREEZE, Brian Scott ,  TAWARAISHI, Taisuke ,  WADA, Yasufumi ,  GREENSPAN, Paul D.

IPC: C07H21/00 ,  C07H21/02 ,  A61K31/7084 ,  A61P35/00

CPC classification number: C07H21/02 ,  A61P35/00 ,  C07H21/00

Abstract: The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I), wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：WO2018030550A1

公开(公告)日：2018-02-15

申请号：PCT/JP2017/029695

申请日：2017-08-08

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YAMAMOTO, Satoshi ,  SHIRAI, Junya ,  KONO, Mitsunori ,  SHIOKAWA, Zenyu ,  YUKAWA, Tomoya ,  IMADA, Takashi ,  NEGORO, Nobuyuki ,  ODA, Tsuneo ,  SASAKI, Satoshi ,  NARA, Yoshi ,  SUZUKI, Shinkichi ,  SATO, Ayumu ,  ISHII, Naoki ,  SHIBUYA, Akito ,  NAKAGAWA, Yasuo ,  COLE, Derek ,  GIBSON, Tony ,  IVETAC, Anthony ,  SWANN, Steve ,  TYHONAS, John

IPC: C07D401/14 ,  C07D215/06 ,  C07D311/44 ,  C07D311/68 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D471/04 ,  C07D265/36 ,  C07D498/04 ,  A61K31/352 ,  A61K31/353 ,  A61K31/4353 ,  A61K31/47 ,  A61K31/536 ,  A61P35/00

Abstract: The present invention relates to a compound that may have an ROR(gamma)t modulating activity and can thus be useful in the treatment of cancer.

Abstract translation: 本发明涉及可具有ROR（γ）t调节活性并因此可用于治疗癌症的化合物。

公开(公告)号：WO2008139941A1

公开(公告)日：2008-11-20

申请号：PCT/JP2008/058310

申请日：2008-04-23

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  KUROITA, Takanobu ,  ODA, Tsuneo ,  ASANO, Yasutomi ,  TAYA, Naohiro ,  IWANAGA, Kouichi ,  TOKUHARA, Hidekazu ,  FUKASE, Yoshiyuki

Inventor： KUROITA, Takanobu ,  ODA, Tsuneo ,  ASANO, Yasutomi ,  TAYA, Naohiro ,  IWANAGA, Kouichi ,  TOKUHARA, Hidekazu ,  FUKASE, Yoshiyuki

IPC: A61K31/497 ,  A61P9/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D403/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention relates to a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof or a prodrug thereof. The compound of the present invention has a superior renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.

Abstract translation: 本发明涉及由下式表示的化合物：其中每个符号如说明书中所定义，或其盐或其前药。 本发明的化合物具有优异的肾素抑制活性，因此可用作预防或治疗高血压，高血压引起的各种器官损害等。

公开(公告)号：WO2020158958A1

公开(公告)日：2020-08-06

申请号：PCT/JP2020/004444

申请日：2020-01-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： HATTORI, Yasushi ,  MIYANOHANA, Yuhei ,  KAJITA, Yuichi ,  KOIKE, Tatsuki ,  HOASHI, Yasutaka ,  TOKUNAGA, Norihito ,  PAWLICZEK, Alexander Martin ,  ODA, Tsuneo ,  MIYAZAKI, Tohru ,  ITO, Yoshiteru ,  TAKEUCHI, Kohei ,  IMAMURA, Keisuke ,  SUGIMOTO, Takahiro

IPC: A61P3/00 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  C07D207/14 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D407/06 ,  C07D413/10 ,  C07D417/10

Abstract: The present invention provides a heterocyclic compound having an orexin type 2 receptor agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof has an orexin type 2 receptor agonist activity, and is useful as an agent for the prophylaxis or treatment of narcolepsy.

公开(公告)号：WO2018100558A8

公开(公告)日：2018-06-07

申请号：PCT/IB2017/057588

申请日：2017-12-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YOSHIKAWA, Masato ,  SAITOH, Morihisa ,  KATO, Taisuke ,  YOSHITOMI, Yayoi ,  SEKI, Tomohiro ,  NAKAGAWA, Yasuo ,  TOMINARI, Yusuke ,  SETO, Masaki ,  SASAKI, Yusuke ,  OKANIWA, Masanori ,  ODA, Tsuneo ,  SHIBUYA, Akito ,  HIDAKA, Kosuke ,  SHIOKAWA, Zenyu ,  MURATA, Shumpei ,  OKABE, Atsutoshi ,  NAKADA, Yoshihisa ,  MOCHIZUKI, Michiyo ,  FREEZE, Brian Scott ,  TAWARAISHI, Taisuke ,  WADA, Yasufumi ,  GREENSPAN, Paul D.

IPC: C07H21/00 ,  C07H21/02 ,  A61K31/7084 ,  A61P35/00

Abstract: The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：WO2016002968A1

公开(公告)日：2016-01-07

申请号：PCT/JP2015/069370

申请日：2015-06-30

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YAMAMOTO, Satoshi ,  SHIRAI, Junya ,  ODA, Tsuneo ,  KONO, Mitsunori ,  OCHIDA, Atsuko ,  IMADA, Takashi ,  TOKUHARA, Hidekazu ,  TOMATA, Yoshihide ,  ISHII, Naoki ,  TAWADA, Michiko ,  FUKASE, Yoshiyuki ,  YUKAWA, Tomoya ,  FUKUMOTO, Shoji

IPC: C07D217/14 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D471/04 ,  C07D491/14 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P43/00

CPC classification number: C07D217/26 ,  A61K31/4375 ,  A61K31/472 ,  A61K31/4741 ,  C07D217/14 ,  C07D471/04 ,  C07D491/048 ,  C07D491/056 ,  C07D491/14 ,  C07F7/0812

Abstract: Provided are heterocyclic compounds having a RORγt inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

Abstract translation: 提供具有由式（I）表示的RORγt抑制作用的杂环化合物：其中每个符号如说明书中所定义，或其盐。

公开(公告)号：WO2018100558A9

公开(公告)日：2018-06-07

申请号：PCT/IB2017/057588

申请日：2017-12-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YOSHIKAWA, Masato ,  SAITOH, Morihisa ,  KATO, Taisuke ,  YOSHITOMI, Yayoi ,  SEKI, Tomohiro ,  NAKAGAWA, Yasuo ,  TOMINARI, Yusuke ,  SETO, Masaki ,  SASAKI, Yusuke ,  OKANIWA, Masanori ,  ODA, Tsuneo ,  SHIBUYA, Akito ,  HIDAKA, Kosuke ,  SHIOKAWA, Zenyu ,  MURATA, Shumpei ,  OKABE, Atsutoshi ,  NAKADA, Yoshihisa ,  MOCHIZUKI, Michiyo ,  FREEZE, Brian Scott ,  TAWARAISHI, Taisuke ,  WADA, Yasufumi ,  GREENSPAN, Paul D.

IPC: C07H21/00 ,  C07H21/02 ,  A61K31/7084 ,  A61P35/00

Abstract: The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：WO2018100558A3

公开(公告)日：2018-06-07

申请号：PCT/IB2017/057588

申请日：2017-12-01

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： YOSHIKAWA, Masato ,  SAITOH, Morihisa ,  KATO, Taisuke ,  YOSHITOMI, Yayoi ,  SEKI, Tomohiro ,  NAKAGAWA, Yasuo ,  TOMINARI, Yusuke ,  SETO, Masaki ,  SASAKI, Yusuke ,  OKANIWA, Masanori ,  ODA, Tsuneo ,  SHIBUYA, Akito ,  HIDAKA, Kosuke ,  SHIOKAWA, Zenyu ,  MURATA, Shumpei ,  OKABE, Atsutoshi ,  NAKADA, Yoshihisa ,  MOCHIZUKI, Michiyo ,  FREEZE, Brian Scott ,  TAWARAISHI, Taisuke ,  WADA, Yasufumi ,  GREENSPAN, Paul D.

IPC: C07H21/00 ,  C07H21/02 ,  A61K31/7084 ,  A61P35/00

Abstract: The present disclosure provides a compound having a STING (stimulator of interferon genes) agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases, such as cancer. The present disclosure relates to a compound represented by the formula (I) wherein each symbol is as defined in the description, or a salt thereof.

公开(公告)号：WO2007094513A3

公开(公告)日：2007-08-23

申请号：PCT/JP2007/053242

申请日：2007-02-15

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED ,  KUROITA, Takanobu ,  IMAEDA, Yasuhiro ,  TAYA, Naohiro ,  ODA, Tsuneo ,  IWANAGA, Kouichi ,  ASANO, Yasutomi

Inventor： KUROITA, Takanobu ,  IMAEDA, Yasuhiro ,  TAYA, Naohiro ,  ODA, Tsuneo ,  IWANAGA, Kouichi ,  ASANO, Yasutomi

IPC: C07D403/06 ,  C07D409/14 ,  C07D401/14 ,  C07D405/14 ,  C07D403/14 ,  C07D417/14 ,  C07D413/14 ,  C07D409/06 ,  A61K31/497 ,  A61P9/12

Abstract: The present invention relates to a compound represented by the formula:( I ) wherein ring A is a 5- or 6-membered aromatic heterocycle optionally having substituent (s); U, V and W are each independently C or N, provided that when any one of U, V and W is N, then the others should be C; Ra and Rb are each independently a cyclic group optionally having substituent (s), a C 1-10 alkyl group optionally having substituent (s), a C 2-10 alkenyl group optionally having substituent (s), or a C 2-10 alkynyl group optionally having substituent (s); X is a bond, or a spacer having 1 to 6 atoms in the main chain; Y is a spacer having 1 to 6 atoms in the main chain; Rc is a hydrocarbon group optionally containing heteroatom(s) as the constituting atom(s), which optionally has substituent (s); m and n are each independently 1 or 2; and ring B optionally further has substituent (s), or a salt thereof. The compound of the present invention has excellent renin inhibitory activity, and thus is useful as an agent for the prophylaxis or treatment of hypertension, various organ damages attributable to hypertension, and the like.