公开(公告)号：WO2011147425A1

公开(公告)日：2011-12-01

申请号：PCT/EE2011/000005

申请日：2011-05-27

Applicant: TALLINN UNIVERSITY OF TECHNOLOGY ,  FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  LAURI, Kai ,  LUMAN, Merike

Inventor： FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  LAURI, Kai ,  LUMAN, Merike

IPC: G01N21/33 ,  G01N21/85 ,  G01N33/62 ,  G01N33/70

CPC classification number: G01N21/33 ,  G01N21/05 ,  G01N21/85

Abstract: Method and device for monitoring removal of hardly or easily diffusible uremic retention solutes during dialysis and for measuring concentration of said substances in a biological fluid, and more specifically in the spent dialysate, for estimation of dialysis dose on dialysis patients. Measurements are performed optically utilizing spectrum of the biological fluid and a concentration calculation algorithm containing the transforming function, including a unique set of optical spectral components at certain wavelengths, to determine the concentration of the substances in specimens in-vitro or flowing fluids on-line. Method and device determines the concentration of the substances in-vitro or on-line utilizing a measuring cuvette suitable for specified measurements. This enables monitoring quantitatively concentrations of substances in a biological fluid and calculation of the dialysis dose for hardly or easily diffusible uremic retention solutes, suitable for automatic and time-efficient way to review the dialysis quality delivered to the end stage renal disease patients.

Abstract translation: 用于监测在透析期间几乎或易于扩散的尿毒症保留溶质的去除以及用于测量生物流体中所述物质的浓度，更具体地，在用过的透析液中的浓度来估计透析患者的透析剂量的方法和装置。 使用生物流体的光谱进行光学测量，以及包含变换功能的浓度计算算法，包括在特定波长处的一组独特的光谱分量，以确定样品中体外或流动流体在线的物质浓度 。 方法和装置使用适合于特定测量的测量杯来体外或在线确定物质的浓度。 这使得能够定量监测生物流体中的物质浓度，并计算透析剂量，用于难溶或易扩散的尿毒症保留溶质，适用于自动和时间有效的方式来检查递送给终末期肾病患者的透析质量。

公开(公告)号：WO2022208445A2

公开(公告)日：2022-10-06

申请号：PCT/IB2022/053039

申请日：2022-03-31

Applicant: TALLINN UNIVERSITY OF TECHNOLOGY

Inventor： ARUND, Jürgen ,  TANNER, Risto ,  FRIDOLIN, Ivo ,  PAATS, Joosep

IPC: G01N21/64 ,  G01N21/33 ,  G01N21/85 ,  A61M1/16 ,  G01N33/49 ,  G01J3/42 ,  G01J3/44 ,  G01J3/0264 ,  G01J3/4406 ,  G01N2021/6421 ,  G01N2021/6491 ,  G01N21/6486 ,  G01N33/493

Abstract: The invention relates to a novel method and a device for quantitative concentration measurements of protein bound and middle sized uremic toxins and advanced glycation end-products in the biological fluids, preferably in the spent dialysate. Invetion combines unique spectral ranges of fluorescence and absorption to determine concentration of uremic toxins, such as indoxyl sulfate, beta-2-microglobulin and 4-pyridoxic acid in a way that provides significantly higher precicion than previously known solutions.

公开(公告)号：WO2012000521A1

公开(公告)日：2012-01-05

申请号：PCT/EE2011/000008

申请日：2011-06-28

Applicant: TALLINN UNIVERSITY OF TECHNOLOGY ,  FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  TANNER, Risto ,  ARUND, Jürgen

Inventor： FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  TANNER, Risto ,  ARUND, Jürgen

IPC: G01N33/52 ,  A61B5/145 ,  G01N21/31

CPC classification number: G01N21/6486

Abstract: This invention relates to a novel method and a device for determining middle and protein bound uremic toxins in the biological fluids. More specifically, the present invention relates to an optical method utilizing fluorescence, preferable fluorescence of the spent dialysate, and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of the middle and protein bound uremic toxins such as beta2-microglobulin (B2M), and indoxyl sulfate (IS).

Abstract translation: 本发明涉及一种用于测定生物体液中中蛋白结合的尿毒症毒素的新方法和装置。 更具体地说，本发明涉及一种使用荧光，优选的透析液的荧光的光学方法以及包括特定波长的独特的一组光谱分量的特定模型，以确定在线优选的浓度 中等和蛋白质结合的尿毒症毒素如β2-微球蛋白（B2M）和硫酸吲哚硫酸盐（IS）。

公开(公告)号：WO2009071102A1

公开(公告)日：2009-06-11

申请号：PCT/EE2008/000026

申请日：2008-12-04

Applicant: TALLINN UNIVERSITY OF TECHNOLOGY ,  FRIDOLIN, Ivo ,  JEROTSKAJA, Jana ,  LAURI, Kai ,  LUMAN, Merike

Inventor： FRIDOLIN, Ivo ,  JEROTSKAJA, Jana ,  LAURI, Kai ,  LUMAN, Merike

IPC: G01N21/33 ,  A61M1/16 ,  G01N33/487

CPC classification number: G01N21/33

Abstract: A method and a device for measuring concentration of substances, preferable uric acid, in biological fluids. Measurements are performed optically-utilizing spectrum of the biological fluid, the Savitzky-Golay algorithm, and a concentration calculation algorithm containing the transforming function to determine the concentration of the substances in specimens in vitro or flowing fluids on-line. The method and device determines the concentration of the substances in-vitro or on-line utilizing a measuring cuvette suitable for specified measurements.

Abstract translation: 用于测量生物流体中物质浓度，优选尿酸的方法和装置。 采用光谱利用生物流体谱，Savitzky-Golay算法和含有转化功能的浓度计算算法进行测量，以确定体外或流体流体在线样品中物质的浓度。 该方法和装置使用适合于特定测量的测量杯来体外或在线测定物质的浓度。

公开(公告)号：EP3537135A1

公开(公告)日：2019-09-11

申请号：EP18160068.5

申请日：2018-03-05

Applicant: Tallinn University of Technology

Inventor： FRIDOLIN, Ivo ,  KALLE, Sigrid ,  TANNER, Risto

IPC: G01N21/64 ,  A61M1/16

Abstract: A novel method and a device for assessment of the concentration of advanced glycation end products (AGE), such as pentosidine in particular, in the biological fluids, such as spent dialysate. More specifically, the present invention relates to an optical method utilizing fluorescence and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of an AGE compound, such as pentosidine.

公开(公告)号：EP2585830A1

公开(公告)日：2013-05-01

申请号：EP11740556.3

申请日：2011-06-28

Applicant: Tallinn University Of Technology

Inventor： FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  TANNER, Risto ,  ARUND, Jürgen

IPC: G01N33/52 ,  A61B5/145 ,  G01N21/31

CPC classification number: G01N21/6486

Abstract: This invention relates to a novel method and a device for determining middle and protein bound uremic toxins in the biological fluids. More specifically, the present invention relates to an optical method utilizing fluorescence, preferable fluorescence of the spent dialysate, and a specific model, including a unique set of optical spectral components at certain wavelengths, to determine, preferable on-line, the concentration of the middle and protein bound uremic toxins such as beta2-microglobulin (B2M), and indoxyl sulfate (IS).

Abstract translation: 本发明涉及一种新颖的方法和用于确定性采矿中，在生物流体中的蛋白结合的尿毒症毒素的装置。 更具体地，本发明涉及在光学方法利用荧光，用过的透析液的优选的荧光，和一个特定的模型，包括一组独特的在某些波长的光的光谱分量的，确定性矿，优选的上线，的浓度 中间和蛋白结合尿毒症毒素：如β2-微球蛋白（B2M），和硫酸吲哚酚（IS）。

公开(公告)号：EP2577270A1

公开(公告)日：2013-04-10

申请号：EP11741089.4

申请日：2011-05-27

Applicant: Tallinn University Of Technology

Inventor： FRIDOLIN, Ivo ,  UHLIN, Fredrik ,  JEROTSKAJA, Jana ,  LAURI, Kai ,  LUMAN, Merike

IPC: G01N21/33 ,  G01N21/85 ,  G01N33/62 ,  G01N33/70

CPC classification number: G01N21/33 ,  G01N21/05 ,  G01N21/85

Abstract: Method and device for monitoring removal of hardly or easily diffusible uremic retention solutes during dialysis and for measuring concentration of said substances in a biological fluid, and more specifically in the spent dialysate, for estimation of dialysis dose on dialysis patients. Measurements are performed optically utilizing spectrum of the biological fluid and a concentration calculation algorithm containing the transforming function, including a unique set of optical spectral components at certain wavelengths, to determine the concentration of the substances in specimens in-vitro or flowing fluids on-line. Method and device determines the concentration of the substances in-vitro or on-line utilizing a measuring cuvette suitable for specified measurements. This enables monitoring quantitatively concentrations of substances in a biological fluid and calculation of the dialysis dose for hardly or easily diffusible uremic retention solutes, suitable for automatic and time-efficient way to review the dialysis quality delivered to the end stage renal disease patients.