公开(公告)号：WO1994006500A1

公开(公告)日：1994-03-31

申请号：PCT/US1993008623

申请日：1993-09-14

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SEPETKA, Ivan ,  PHAM, Phong

IPC: A61M25/00

CPC classification number: A61M25/0069 ,  A61M2025/0057

Abstract: A catheter (11) for use in combination with a guide wire (12) for placement within a tortuous, small vessel and delivery of fluid to a target site. The catheter (11) comprises an elongated tubular body with a perforated flexible tip (20) located at the distal end (15) of the elongated tubular body.

Abstract translation: 一种用于与导丝（12）组合使用以用于放置在曲折的小容器内并将流体输送到目标部位的导管（11）。 导管（11）包括细长的管状体，其具有位于细长管状体的远端（15）处的穿孔柔性尖端（20）。

公开(公告)号：WO1993002733A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006422

申请日：1992-08-03

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SEPETKA, Ivan ,  PHAM, Phong ,  ENGELSON, Erik, T.

IPC: A61M25/00

CPC classification number: A61M25/0054

Abstract: A catheter (12) composed of an outer coaxial tube (18) for relatively high flexibility and three tandemly disposed inner coaxial tube segments (19, 20, 21) that vary in stiffness with the stiffest being located at the proximal end (12) of the catheter and the least stiff ending distal (16) of the proximal end of the catheter. The catheter thus has four regions of different stiffness/flexibility.

公开(公告)号：WO1992019151A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003896

申请日：1992-05-06

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SEPETKA, Ivan

IPC: A61B05/00

CPC classification number: A61M25/09 ,  A61M25/0054 ,  A61M2025/09091 ,  A61M2025/09166 ,  A61M2025/09175

Abstract: A catheter guide wire (10) comprising: a flexible, torqueable proximal wire section (13), a more flexible intermediate section (14) with a flexible polymer tube covering (19), and a most flexible distal end section (15). A helical ribbon coil (22) is wrapped about the intermediate core segment between the wire core and the polymer tube covering to increase radiopacity and improve torque transmission while retaining flexibility.

Abstract translation: 导管导丝（10），包括：柔性的，可扭转的近侧线段（13），具有柔性聚合物管覆盖物（19）的更灵活的中间部分（14）和最柔性的远端部分（15）。 螺旋带状线圈（22）围绕线芯和聚合物管覆盖物之间的中间纤芯段缠绕以增加不透射线性并且在保持柔性的同时提高扭矩传递。

公开(公告)号：WO1990014123A1

公开(公告)日：1990-11-29

申请号：PCT/US1990002791

申请日：1990-05-22

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  ENGELSON, Erik, T. ,  SEPETKA, Ivan

IPC: A61M25/00

CPC classification number: A61M25/01 ,  A61M25/0012 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/09 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/09091

Abstract: A catheter (12) for accessing a target site along a tortuous, small-vessel pathway. The catheter includes a flexible distal segment (26) which is composed of a flexible polymer tube and a low-friction internal tubular surface. The surface allows the catheter to be advanced over sharp bends and small-diameter loops in a guidewire (14), in advancing the catheter along a small-vessel pathway. Various embodiments of the catheter are disclosed wherein the internal tubular surface of a distal portion of the catheter include a variety of different constructions and are comprised of a variety of different materials so as to best avoid the jamming, sticking or locking of the distal end or any part of the guidewire against the surface. Braided sleeve-like constructions, surfaces embedded with a plurality of small particles and surfaces comprised of various anti-friction materials are used in order to obtain the object of the invention.

公开(公告)号：WO1993011823A1

公开(公告)日：1993-06-24

申请号：PCT/US1992010462

申请日：1992-12-04

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SEPETKA, Ivan

IPC: A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/1214 ,  A61B90/39 ,  A61B2017/12095

Abstract: A pusher-vasoocclusive coil assembly (11) that is advanced through a catheter (24) to a site within a vessel and is manipulated to detach the coil (13) from the assembly. The pusher (12) has a distal end (17) that is initially threaded into the proximal end of the coil (13) and the assembly (11) includes a sleeve (14) that is slid over the pusher (12) and whose distal edge abuts the proximal end of the coil (13) to hold the coil (13) in place while the distal end of the pusher (12) is threaded out of the coil (13) to detach the coil (13) at the site.

公开(公告)号：EP0585359B1

公开(公告)日：1998-03-18

申请号：EP92912258.8

申请日：1992-05-06

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan

IPC: A61M25/01 ,  A61B5/00

CPC classification number: A61M25/09 ,  A61M25/0054 ,  A61M2025/09091 ,  A61M2025/09166 ,  A61M2025/09175

Abstract: A catheter guide wire (10) comprising: a flexible, torqueable proximal wire section (13), a more flexible intermediate section (14) with a flexible polymer tube covering (19), and a most flexible distal end section (15). A helical ribbon coil (22) is wrapped about the intermediate core segment between the wire core and the polymer tube covering to increase radiopacity and improve torque transmission while retaining flexibility.

Abstract translation: 一种导管引导线（10），包括：柔性的可扭转的近端线部分（13），具有柔性聚合物管覆盖物（19）的更柔性的中间部分（14）以及最柔性的远端部分（15）。 螺旋带状线圈（22）缠绕在线芯和聚合物管覆盖物之间的中间芯段上，以增加射线不透性并改善扭矩传递，同时保持柔性。

公开(公告)号：EP0473697B1

公开(公告)日：1996-08-14

申请号：EP90908859.3

申请日：1990-05-22

Applicant: TARGET THERAPEUTICS, INC.

Inventor： ENGELSON, Erik, T. ,  SEPETKA, Ivan

IPC: A61M25/00

CPC classification number: A61M25/01 ,  A61M25/0012 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/09 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/09091

Abstract: A catheter (12) for accessing a target site along a tortuous, small-vessel pathway. The catheter includes a flexible distal segment (26) which is composed of a flexible polymer tube and a low-friction internal tubular surface. The surface allows the catheter to be advanced over sharp bends and small-diameter loops in a guidewire (14), in advancing the catheter along a small-vessel pathway. Various embodiments of the catheter are disclosed wherein the internal tubular surface of a distal portion of the catheter include a variety of different constructions and are comprised of a variety of different materials so as to best avoid the jamming, sticking or locking of the distal end or any part of the guidewire against the surface. Braided sleeve-like constructions, surfaces embedded with a plurality of small particles and surfaces comprised of various anti-friction materials are used in order to obtain the object of the invention.

公开(公告)号：EP0629125B1

公开(公告)日：1998-06-24

申请号：EP92922392.3

申请日：1992-09-30

Applicant: REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  TARGET THERAPEUTICS, INC.

Inventor： GUGLIELMI, Guido ,  SEPETKA, Ivan

IPC: A61B17/38

CPC classification number: A61M25/09 ,  A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/1215 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00292 ,  A61B2017/12063 ,  A61B2017/12095 ,  A61B2017/22038 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/1226 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1266 ,  A61B2018/1435 ,  A61B2018/1495 ,  A61B2090/3966 ,  A61M2025/09175

Abstract: An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire (56) and/or tip (53) into the vascular cavity. The vascular cavity is packed with the tip (58) to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion is formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip (104). The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter (144) are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter (144) is more easily tracked by providing a radiopaque proximal marker (110) on the microcatheter and corresponding indicator marker (112) on the wire. Electrothrombosis is facilitated by placing the ground electrode (114) on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

公开(公告)号：EP0726745B1

公开(公告)日：1998-01-21

申请号：EP95900494.6

申请日：1994-11-01

Applicant: TARGET THERAPEUTICS, INC.

Inventor： PHAM, Pete Phong ,  DOAN, Hong ,  SEPETKA, Ivan

IPC: A61F2/00

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00004 ,  A61B2017/12063

Abstract: This invention is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas. In particular, it deals with a sacrificial link (106) between an endovascular device (104) which is introducted to and is intended to remain at the desired thrombus formation site and the device (102) used to introduce the device. The invention further includes a method for introduction of the device and its electrolytic separation.

公开(公告)号：EP0616544B1

公开(公告)日：1997-09-24

申请号：EP93900854.6

申请日：1992-12-04

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan

IPC: A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/1214 ,  A61B90/39 ,  A61B2017/12095

Abstract: A pusher-vasoocclusive coil assembly (11) that is advanced through a catheter (24) to a site within a vessel and is manipulated to detach the coil (13) from the assembly. The pusher (12) has a distal end (17) that is initially threaded into the proximal end of the coil (13) and the assembly (11) includes a sleeve (14) that is slid over the pusher (12) and whose distal edge abuts the proximal end of the coil (13) to hold the coil (13) in place while the distal end of the pusher (12) is threaded out of the coil (13) to detach the coil (13) at the site.