公开(公告)号：WO2009042708A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077555

申请日：2008-09-24

Applicant: TECHNOLOGY COMMERCIALIZATION CORP.

Inventor： LOPATINA, Ekaterina, V. ,  KARETSKIY, Andrey, V. ,  KRYLOV, Boris, Vladimirovich

IPC: C07D315/00

CPC classification number: A61K31/351

Abstract: A regenerative anti-inflammatory composition is described to include 1 to 2 percent of comenic acid and 0.55 to 1.1 percent of sodium hydrocarbonate in a water solution, with an optional additive of up to 2.5 percent of benzyl-comenic acid. A method of treating a retinal dystrophy by injecting this composition parabulbarly or intravenously in appropriate amounts is also described. A non-peptide nature of the compound allows reducing side effects commonly associated with peptide-based compounds presently used for treatment of such dystrophy. Water-based solution of the composition is stable and amenable for storage in ampoules ready for injection thus obviating a need to make a solution from a powder, which is a common step with current treatment compounds.

Abstract translation: 描述了一种再生性抗炎组合物，其在水溶液中包含1至2％的共聚酸和0.55至1.1％的碳酸氢钠，其中任选的添加剂高达2.5％的苄基 - 苯甲酸。 还描述了通过以适量的方式或静脉内注射该组合物来治疗视网膜营养不良的方法。 化合物的非肽性质允许减少通常与目前用于治疗这种营养不良的基于肽的化合物相关的副作用。 组合物的水基溶液是稳定的并且适于储存在准备好注射的安瓿中，从而避免需要从粉末中制备溶液，这是当前处理化合物的常见步骤。