公开(公告)号：US20160108090A1

公开(公告)日：2016-04-21

申请号：US14893800

申请日：2014-05-23

Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： Yeon Sun LEE ,  Victor J. HRUBY ,  Frank PORRECA ,  Josephine LAI

IPC: C07K7/64 ,  C07K7/08

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/08 ,  C07K14/665

Abstract: Described are Dynorphin A analog compounds and uses thereof for treating pain in humans and lower animals by administering to a human or lower animal in need of treatment. The compounds interact with the bradykinin receptor to relieve pain. Preferred compounds are amphipathic [Des-Arg7]-dynorphin A peptide analogs and specific cyclic dynorphin A peptide analogs.

Abstract translation: 描述的是Dynorphin A类似物及其用于治疗需要治疗的人或低等动物的人和低等动物的疼痛的用途。 化合物与缓激肽受体相互作用以缓解疼痛。 优选的化合物是两亲性[Des-Arg7] - 吗啡A肽类似物和特定的环状强啡肽A肽类似物。