公开(公告)号：EP0445239A4

公开(公告)日：1992-03-25

申请号：EP90909947

申请日：1990-06-14

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RATHOD, PRADIPSINH, K.

IPC: A61K31/00 ,  A61K31/505 ,  A61K31/513 ,  A61K31/52 ,  A61K31/70 ,  A61K45/06 ,  A61P33/02 ,  A61K

CPC classification number: A61K31/70 ,  A61K31/00 ,  A61K31/505 ,  A61K31/513 ,  A61K45/06 ,  Y10S514/885 ,  A61K2300/00

Abstract: Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue inhibitors of nucleic acid biosynthesis, e.g., 5-fluoro-orotic acid, alone or together with one or more "rescue" compounds, e.g., a normal pyrimidine base or nucleoside that can be used by the host vertebrate, but not by malaria-causing parasites, for nucleic acid biosynthesis. Also claimed are methods of prophylactic and therapeutic use of these compositions.