-
1.发明申请
公开(公告)号：WO2021033082A1
公开(公告)日：2021-02-25
申请号：PCT/IB2020/057588
申请日：2020-08-12
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
Abstract: Described is hybrid viral vector comprising: a first virus such as bacteriophage T4; one or more second virus such as adeno-associated virus (AAV) attached to the first virus through cross-bridges, such as avidin-biotin cross-bridges; one or more DNA molecules packaged in the first virus; one or more nucleic acid molecules packaged in the second virus; and one or more proteins displayed on the surface of the first virus. Also described are methods of making and using such a hybrid viral vector.
-
2.发明申请
公开(公告)号：WO2022130196A1
公开(公告)日：2022-06-23
申请号：PCT/IB2021/061688
申请日：2021-12-14
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N7/00 , C12N9/22 , C07K14/005 , A61K39/215 , C12N15/70
Abstract: The present disclosure relates to a system for and a method of incorporating SARS-CoV-2 genes and proteins into T4 phages. The present disclosure also relates to vaccine against SARS-CoV-2 containing recombinant T4 phages created using the method provided in the present disclosure.
-
公开(公告)号：WO2022023850A1
公开(公告)日：2022-02-03
申请号：PCT/IB2021/056248
申请日：2021-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N15/86 , C12N15/113 , C12N9/22 , C12N15/10 , C12N15/88 , A61K48/00 , A61K31/7088 , C12N2795/00043 , C12N2795/00051 , C12N7/00
Abstract: Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
-
公开(公告)号：EP4514386A1
公开(公告)日：2025-03-05
申请号：EP23795745.1
申请日：2023-04-25
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： ZHU, Jingen , RAO, Venigalla B.
IPC: A61K39/215 , A61K39/385 , A61P31/14 , A61K39/00
-
Patent Agency Ranking
公开(公告)号：EP4371564A3
公开(公告)日：2024-08-21
申请号：EP24155130.8
申请日：2021-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: A61K31/7088 , C12N7/00 , C12N15/10 , C12N15/86
CPC classification number: C12N15/86 , C12N2795/1014320130101 , C12N2795/1014220130101 , C12N15/102 , C12N2795/1012120130101 , C12N7/00 , C12N2310/2020170501
Abstract: Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
-
6.发明公开
公开(公告)号：EP4017986A1
公开(公告)日：2022-06-29
申请号：EP20855101.0
申请日：2020-08-12
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
-
公开(公告)号：EP4371564A2
公开(公告)日：2024-05-22
申请号：EP24155130.8
申请日：2021-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: A61K31/7088
CPC classification number: C12N15/86 , C12N2795/1014320130101 , C12N2795/1014220130101 , C12N15/102 , C12N2795/1012120130101 , C12N7/00 , C12N2310/2020170501
Abstract: Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.
-
8.发明公开
公开(公告)号：EP4263811A1
公开(公告)日：2023-10-25
申请号：EP21905936.7
申请日：2021-12-14
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N7/00 , C12N9/22 , C07K14/005 , A61K39/215 , C12N15/70
-
公开(公告)号：EP4189096A1
公开(公告)日：2023-06-07
申请号：EP21850710.1
申请日：2021-07-21
Applicant: THE CATHOLIC UNIVERSITY OF AMERICA
Inventor： RAO, Venigalla B. , ZHU, Jingen
IPC: C12N15/86 , C12N15/113 , C12N9/22 , C12N15/10 , C12N15/88 , A61K48/00 , A61K31/7088
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.043 seconds)
