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    ION SELECTIVE ELECTRODES FOR DIRECT ORGANIC DRUG ANALYSIS IN SALIVA, SWEAT, AND SURFACE WIPES
    1.
    发明申请
    ION SELECTIVE ELECTRODES FOR DIRECT ORGANIC DRUG ANALYSIS IN SALIVA, SWEAT, AND SURFACE WIPES 审中-公开
    用于SALIVA，SWEAT和SURFACE WIPES中直接有机药物分析的离子选择性电极

    公开(公告)号：WO2003034056A1

    公开(公告)日：2003-04-24

    申请号：PCT/US2002/029551

    申请日：2002-09-13

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY

    Inventor： KIDWELL, David, A.

    IPC: G01N27/333

    CPC classification number: G01N33/48714 ,  G01N27/3335

    Abstract: A hand-held portable drug monitoring system to detect and quantitate cocaine and other organic drugs in saliva, sweat, and surface wipes by using an ion selective electrode or an array of ion selective electrodes. The ion selective electrode has a cast membrane reference electrode and a sensing electrode with a hydrophobic polymer, a plasticizer, and an ionophore selective for the organic drug to be tested. The ion selective electrode can be connected to a converter that coverts a voltage reading from the ion selective electrode to a quantitative drug concentration level. Also disclosed is the related method of using an ion selective electrode to detect an organic drug in saliva, sweat, and surface wipes, the method of testing electrical contact in an ion selective electrode, and the method of making a cast membrane reference electrode.

    Abstract translation: 手提便携式药物监测系统，通过使用离子选择性电极或离子选择性电极阵列来检测和定量唾液，汗液和表面擦拭物中的可卡因和其他有机药物。 离子选择电极具有铸膜参比电极和具有疏水性聚合物，增塑剂和对待测有机药物选择性的离子载体的感测电极。 离子选择电极可以连接到转换器，其将从离子选择性电极读取的电压覆盖到定量药物浓度水平。 还公开了使用离子选择电极检测唾液，汗液和表面擦拭物中的有机药物的相关方法，测试离子选择性电极中的电接触的方法以及制备流延膜参比电极的方法。

    MICROASSAY ON A CARD
    2.
    发明申请
    MICROASSAY ON A CARD 审中-公开
    微笑在卡上

    公开(公告)号：WO1992004612A1

    公开(公告)日：1992-03-19

    申请号：PCT/US1991006395

    申请日：1991-09-06

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ...

    Inventor： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ... ,  KIDWELL, David, A.

    IPC: G01N21/03

    CPC classification number: G01N33/54386 ,  B01L3/5023 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/29 ,  G01N21/76 ,  G01N21/78 ,  G01N33/525 ,  G01N2201/04 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/967 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

    Abstract: A microassay card (10) includes an upper layer (12) containing wells (14) for receiving a liquid sample (16). A second layer (20) of the card (10), beneath the first layer (12), includes a supporting surface (223) bound to a reactive species (114). A third layer (26) includes a superabsorbent support (26) impregnated with an indicator (228). Typically, the indicator (228) is a substrate (228) for an enzyme (16), such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme (116), upon the substrate to cause a spectral change in the absorbent layer (26). By selecting the structure of the first (12) and second (20) layers, the card (10) can be formatted for a displacement assay or a competitive assay. The microassay card (10) of the present invention is particularly useful for drug testing.

    Abstract translation: 微型卡片（10）包括含有用于接收液体样品（16）的孔（14）的上层（12）。 在第一层（12）下方的卡（10）的第二层（20）包括结合到反应物种（114）的支撑表面（223）。 第三层（26）包括浸渍有指示剂（228）的超吸收剂载体（26）。 通常，指示剂（228）是用于酶（16）的底物（228），例如还原的染料前体和用于酶（116）作用所必需的过氧化氢源，在底物上引起光谱 改变吸收层（26）。 通过选择第一层（12）和第二（20）层的结构，卡（10）可以被格式化用于位移测定或竞争性测定。 本发明的微量测定卡（10）对于药物测试特别有用。

    EXCESS ENTHALPY UPON PRESSURIZATION OF NANOSIZED METALS WITH DEUTERIUM
    3.
    发明申请
    EXCESS ENTHALPY UPON PRESSURIZATION OF NANOSIZED METALS WITH DEUTERIUM 审中-公开
    纳米金属与脱氧核糖核酸的加压过程

    公开(公告)号：WO2011041370A1

    公开(公告)日：2011-04-07

    申请号：PCT/US2010/050662

    申请日：2010-09-29

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY ,  KIDWELL, David, A.

    Inventor： KIDWELL, David, A.

    IPC: G01F25/00

    CPC classification number: G01N25/48 ,  B01J21/04 ,  B01J23/42 ,  B01J23/44 ,  B01J23/63 ,  B01J29/04

    Abstract: A method for producing excess enthalpy by impregnating metallic precursors on an oxide support that reduces sintering and particle growth; drying the impregnated support at a temperature where the particle growth is minimal; reducing the metallic precursors at a second temperature where the particle growth results in supported metallic particles 2 nm or less in size; and pressurizing the supported metallic particles in the presence of deuterium. The metal particles may comprise palladium, platinum, mixtures thereof, or mixtures of palladium and/or platinum with other elements. Also disclosed is a method for measuring excess enthalpy by placing a test material in a pressure vessel; heating the pressure vessel; evacuating the pressure vessel; introducing deuterium, hydrogen, or both into the pressure vessel; measuring the enthalpy generated during pressurization; again evacuating the pressure vessel; and measuring the enthalpy used during depressurization.

    Abstract translation: 通过将金属前体浸渍在减少烧结和颗粒生长的氧化物载体上产生过量焓的方法; 在颗粒生长最小的温度下干燥浸渍的载体; 在第二温度下还原金属前体，其中颗粒生长导致尺寸为2nm或更小的负载金属颗粒; 并在氘存在下对负载的金属颗粒加压。 金属颗粒可以包括钯，铂，其混合物，或钯和/或铂与其它元素的混合物。 还公开了一种通过将测试材料放置在压力容器中来测量过量焓的方法; 加热压力容器; 排空压力容器; 将氘，氢或二者引入压力容器中; 测量加压过程中产生的焓; 再次抽空压力容器; 并测量在减压期间使用的焓。

    MULTIPARAMETER SYSTEM FOR ENVIRONMENTAL MONITORING
    4.
    发明申请
    MULTIPARAMETER SYSTEM FOR ENVIRONMENTAL MONITORING 审中-公开
    用于环境监测的多参数系统

    公开(公告)号：WO2005057199A1

    公开(公告)日：2005-06-23

    申请号：PCT/US2004/041844

    申请日：2004-12-03

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY ,  KIDWELL, David, A.

    Inventor： KIDWELL, David, A.

    IPC: G01N27/26

    CPC classification number: G01N33/18

    Abstract: A miniature, lightweight, inexpensive, environmental monitoring system containing a number of sensors that can simultaneously and continuously monitor fluorescence, absorbance, conductivity, temperature, and several ions. Sensors that monitor similar parameters can cross-check data to increase the likelihood that a problem with the water will be discovered.

    Abstract translation: 一个微型，轻便，便宜的环境监测系统，其中包含许多可同时连续监测荧光，吸光度，电导率，温度和几种离子的传感器。 监测类似参数的传感器可以交叉检查数据，以增加发现水的问题的可能性。

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