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公开(公告)号：EP0216467A3
公开(公告)日：1988-09-28
申请号：EP86305743
申请日：1986-07-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A.
IPC: C12M01/40
Abstract: Enzyme electrode assembly suitable for sensing physiologically important molecules such as glucose wherein the rate of accessibility of enzyme substrates to the enzyme (18,24) is differentially regulated by suitably positioning material with selective permeability (20,26) properties around the sensing region of the electrode assembly.
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2.发明公开Electrochemical cell sensor for continuous, short-term use in tissues and blood 失效电化学细胞传感器用于连续，短期用于组织和血液
公开(公告)号：EP0206531A3
公开(公告)日：1988-07-13
申请号：EP86303946
申请日：1986-05-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A.
CPC classification number: C12Q1/005 , A61B5/14865 , Y10S977/905
Abstract: An electrochemical cell sensor for monitoring oxidizable enzyme substrates in biological fluids situated in a housing and suitable for implantation in the body, including at least one oxygen or hydrogen peroxide sensing electrode containing a suitable oxidase enzyme, a reference electrode, and a counter electrode all in communication with biological fluids through one or more openings in the walls of the housing.
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3.发明授权Electrochemical cell sensor for continuous, short-term use in tissues and blood 失效电化学细胞传感器，用于组织和血液中的短期使用
公开(公告)号：EP0206531B1
公开(公告)日：1993-01-13
申请号：EP86303946.7
申请日：1986-05-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A.
CPC classification number: C12Q1/005 , A61B5/14865 , Y10S977/905
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Patent Agency Ranking4.发明公开Two-dimensional diffusion glucose substrate sensing electrode 失效Glukosesubstratempfindliche zweidimensionale Diffusionselektrode。
公开(公告)号：EP0216467A2
公开(公告)日：1987-04-01
申请号：EP86305743.6
申请日：1986-07-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A.
IPC: C12M1/40
Abstract: Enzyme electrode assembly suitable for sensing physiologically important molecules such as glucose wherein the rate of accessibility of enzyme substrates to the enzyme (18,24) is differentially regulated by suitably positioning material with selective permeability (20,26) properties around the sensing region of the electrode assembly.
Abstract translation: 适用于感测生理上重要的分子（例如葡萄糖）的酶电极组件，其中酶底物对酶（18,24）的可达性速率通过适当地定位在具有选择性渗透性（20,26）性质的材料周围的差异调节 电极组件。
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5.发明授权A complete glucose monitoring system with an implantable, telemetered sensor module 失效用于与可植入的传感器模块，其用于远程测量葡萄糖监测完整的系统。
公开(公告)号：EP0245073B1
公开(公告)日：1993-12-22
申请号：EP87303993.7
申请日：1987-05-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A. , Lucisano, Joseph Y. , Armour, Jon C. , McKean, Brian D.
IPC: G01N27/416 , A61B5/00 , G01N33/48
CPC classification number: A61B5/14865 , A61B5/0031 , Y10S128/903
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6.发明公开Method for increasing the service life of an implantable sensor 失效Verfahren zurErhöhungder Funktionslebensdauer eines implierbarenFühlers。
公开(公告)号：EP0567725A1
公开(公告)日：1993-11-03
申请号：EP93101060.7
申请日：1993-01-25
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A. , Lucisano, Joseph Y.
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/14542 , A61B5/1473 , Y10S128/903
Abstract: Methods are described for extending the service life of implantable sensors (2) having a silver-containing anodic reference electrode (4) maintained at a high impedance, at least one noble metal cathodic working electrode (6), and at least one noble metal anodic counter electrode (8) maintained at a low impedance, particularly sensors for the in vivo detection of oxygen and/or glucose in bodily fluids. The methods described involve increasing the input impedance of the reference electrode (4) up to a maximum for implanted circuitry and shielding said electrode, and/or alternating the operating roles of the reference (4) and working (6) electrodes, switching the working electrodes with counter electrodes in the circuit, reversing the polarities of the reference (4) and working (6) electrodes, and sequentially activating each electrode in a plurality of working and/or reference electrodes in the circuit. All of the circuitry means needed to control the steps described can be implanted with the sensor (2) so that the steps can be performed while the sensor is in use in a patient.
Abstract translation: 描述了延长具有保持高阻抗的含银阳极参考电极（4）的可植入传感器（2）的使用寿命的方法，至少一种贵金属阴极工作电极（6）和至少一种贵金属阳极 对电极（8）保持低阻抗，特别是体内检测体液中氧和/或葡萄糖的传感器。 所描述的方法涉及将参考电极（4）的输入阻抗增加到植入电路的最大值并屏蔽所述电极，和/或交替参考电极（4）和工作电极（6）的操作角色，切换工作 在电路中具有相对电极的电极，反转参考电极（4）和工作电极（6）的极性，并且顺序激活电路中的多个工作和/或参考电极中的每个电极。 可以用传感器（2）植入控制所描述的步骤所需的所有电路装置，使得可以在传感器在患者中使用时执行步骤。
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7.发明公开A complete glucose monitoring system with an implantable, telemetered sensor module 失效具有可植入式电传感器模块的完整葡萄糖监测系统
公开(公告)号：EP0245073A3
公开(公告)日：1989-03-29
申请号：EP87303993.7
申请日：1987-05-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A. , Lucisano, Joseph Y. , Armour, Jon C. , McKean, Brian D.
IPC: G01N27/416 , A61B5/00 , G01N33/48
CPC classification number: A61B5/14865 , A61B5/0031 , Y10S128/903
Abstract: An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered and the other contacting glucose oxidase allowing for differential measurement of oxygen content in bodily fluids or tissues indicative of glucose levels. The module includes a communication capability for transmitting measurement information to an external recording device outside the body.
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8.发明公开A complete glucose monitoring system with an implantable, telemetered sensor module 失效VollständigesSystem zur Glucose-Überwachungmit einem einpflanzbaren Sensormodul zur Fernmessung。
公开(公告)号：EP0245073A2
公开(公告)日：1987-11-11
申请号：EP87303993.7
申请日：1987-05-05
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Gough, David A. , Lucisano, Joseph Y. , Armour, Jon C. , McKean, Brian D.
IPC: G01N27/416 , A61B5/00 , G01N33/48
CPC classification number: A61B5/14865 , A61B5/0031 , Y10S128/903
Abstract: An electrochemical system includes a sensor module suitable for implantation in the body to monitor glucose and oxygen levels therein. The module has two oxygen sensors situated in an oxygen-permeable housing, arranged in a tandem relationship, and recessed in the housing, one sensor being unaltered and the other contacting glucose oxidase allowing for differential measurement of oxygen content in bodily fluids or tissues indicative of glucose levels. The module includes a communication capability for transmitting measurement information to an external recording device outside the body.
Abstract translation: 电化学系统包括适于植入体内以监测其中的葡萄糖和氧水平的传感器模块。 该模块具有两个氧气传感器，它们位于氧气可渗透的壳体中，以串联的关系布置，并且在壳体中凹陷，一个传感器不变，另一个接触葡萄糖氧化酶允许差异测量体液或组织中的氧含量， 葡萄糖水平。 该模块包括用于将测量信息发送到身体外部的外部记录装置的通信能力。
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