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公开(公告)号：US20220401960A1
公开(公告)日：2022-12-22
申请号：US17622206
申请日：2020-08-07
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Jia Wang , Alejandra Rios , Philip Chao , Jason Jones
Abstract: A radiosynthesis system is disclosed that leverages droplet microfluidic radiosynthesis and its inherent advantages including reduction of reagent consumption and the ability to achieve high molar activity even when using low starting radioactivity. The radiosynthesis system enables the parallel synthesis of radiolabeled compounds using droplet-sized reaction volumes. In some embodiments, a single heater is used to create multiple reaction or synthesis sites. In other embodiments, separate heaters are used to create independently-controlled heating conditions at the multiple reaction or synthesis sites. In one embodiment, a four-heater setup was developed that utilizes a multi-reaction microfluidic chip and was assessed for the suitability with high-throughput radiosynthesis optimization. Replicates of several radiochemical operations including the full synthesis of various PET tracers revealed the platform to have high repeatability (e.g., consistent fluorination efficiency). The system may also be used for synthesis optimization.
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公开(公告)号：US11660571B2
公开(公告)日：2023-05-30
申请号：US16461272
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Noel S. Ha , Jason Jones , Jimmy Ly , Stephen Liu , Shilin Cheung
IPC: B01D57/02 , G01N27/447 , A61K51/00 , B01L3/00
CPC classification number: B01D57/02 , A61K51/00 , B01L3/502715 , B01L3/502738 , G01N27/44717 , G01N27/44721 , G01N27/44743 , G01N27/44791
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
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公开(公告)号：US20200147548A1
公开(公告)日：2020-05-14
申请号：US16461272
申请日：2017-11-14
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： R. Michael van Dam , Noel S. Ha , Jason Jones , Jimmy Ly , Stephen Liu , Shilin Cheung
Abstract: A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.
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