公开(公告)号：WO1996014942A1

公开(公告)日：1996-05-23

申请号：PCT/US1995014955

申请日：1995-11-15

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  SLOAN, James, W. ,  PAPCIAK, Charles ,  CONARD, William, A.

IPC: B05D05/00

CPC classification number: C23C2/00 ,  A61J1/1425 ,  A61J1/1468 ,  A61J1/18 ,  B32B15/08 ,  B65D51/002 ,  Y10T428/1355

Abstract: A method is provided for reducing particle formation during manufacture of shell caps (12) for pharmaceutical containers (10). The method entails providing a solid polymeric coating (25) on substantially all surfaces of the shell cap (12) to form coated shell caps before permitting the coated shell caps to contact each other or other objects. A pharmaceutical container (10) which employs the shell cap (12) also is provided. The pharmaceutical container (10) comprises a vial (5) for storing medicinal compositions therein and a shell cap (12) for sealing the vial (5). The shell cap (12) includes a hollow metallic preform substrate (1) and a solid polymeric coating (25) which encapsulates the substrate (1). An optional liner (15) can be fitted to the inner surface of the shell cap (12) having the polymeric coating thereon (25) and an optional cover (20) can be provided over the cap (12). When the shell cap (12) is fitted to vial (5), liner (15) engages edge (7) of vial (5) to provide an additional seal top protecting the contents within the vial (5).

Abstract translation: 提供了一种用于在用于药物容器（10）的壳盖（12）的制造期间减少颗粒形成的方法。 该方法需要在壳盖（12）的基本上所有表面上提供固体聚合物涂层（25），以在允许涂覆的壳盖彼此接触或其它物体之前形成涂覆的外壳盖。 还提供了一种采用壳盖（12）的药物容器（10）。 药物容器（10）包括用于储存药物组合物的小瓶（5）和用于密封小瓶（5）的壳盖（12）。 壳盖（12）包括中空金属预成型基板（1）和封装基板（1）的固体聚合物涂层（25）。 可选的衬套（15）可以安装到其上具有聚合物涂层（25）的壳盖（12）的内表面上，并且可以在帽（12）上方设置可选的盖（20）。 当壳盖（12）装配到小瓶（5）时，衬套（15）接合小瓶（5）的边缘（7），以提供保护小瓶（5）内的内容物的附加密封顶部。

公开(公告)号：WO1997003790A1

公开(公告)日：1997-02-06

申请号：PCT/US1995008881

申请日：1995-07-14

Applicant: THE WEST COMPANY, INCORPORATED ,  VANDER BUSH, Edward, F., Jr. ,  TROUTMAN, William, E.

Inventor： THE WEST COMPANY, INCORPORATED

IPC: B23P11/02

CPC classification number: B67B3/14 ,  B65B7/168

Abstract: Method and apparatus for applying a multi-piece closure (C), consisting of a sealing cap (Cc) and inner (Ci) and outer (Co) axially displaceable cover elements, over a rubber stopper (S) fitted in the discharge opening of a vial (B). The apparatus comprises a sealing head assembly including a plurality of jaws (J) and a pressure head (Bp). The vial is first positioned on a spring-biased pressure pad (P), with the multi-piece closure positioned loosely over the stopper. With the jaws in an open position, the pressure head is then lowered toward the vial, causing a cam surface (122) on the pressure head to contact outer ends (120) of the jaws such that the jaws surround and engage the outer cover element. Continued downward movement of the pressure head affects relative axial movement of the sealing cap and the inner and outer cover elements with respect to the stopper until the sealing cap and cover elements are fully seated about an upper lip (8) of the vial.

Abstract translation: 一种用于施加多个封闭件（C）的方法和装置，该多件式封闭件（C）由密封盖（Cc）和内部（Ci）和外部（Co）可轴向移动的盖元件组成，安装在安装在 一个小瓶（B）。 该装置包括一个包括多个钳口（J）和一个压力头（Bp）的密封头组件。 首先将小瓶定位在弹簧偏置的压力垫（P）上，多片式封闭件松动地定位在止动器上。 当钳口处于打开位置时，压力头然后朝向小瓶降低，导致压力头上的凸轮表面（122）接触夹爪的外端（120），使得夹爪围绕并接合外盖元件 。 压头的持续向下运动影响密封盖和内外盖元件相对于止动件的相对轴向移动，直到密封盖和盖元件围绕瓶的上唇（8）完全就位。

公开(公告)号：WO1998002360A1

公开(公告)日：1998-01-22

申请号：PCT/US1997012472

申请日：1997-07-15

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  NORTON, Paul, H.

IPC: B65D33/16

CPC classification number: A61L2/26 ,  A61B50/31 ,  A61B2050/314 ,  B01L1/02

Abstract: A container (10) for holding elements (12) to be sterilized prior to introduction into an isolation system. The container includes a flexible bag (14) having a first end (14a) defining a first opening for removing the elements. The bag includes a transfer port (26) that is engageable with the isolation system for transferring the sterilized elements into the isolation system. The transfer port has a bore (30) extending through it. The exterior surface (28) of the bore has a clamp receiving area (32) and a groove (34). The first end of the bag is located in the groove. A clamp (38) is located around the flexible bag near the first end. A portion of the flexible bag is clamped between the clamp and the clamp receiving area on the transfer port. A sealing material (44) is located in the groove and encapsulates the first end of the flexible bag to form a hermetical seal.

Abstract translation: 一种用于在引入隔离系统之前保持待消毒的元件（12）的容器（10）。 容器包括具有限定用于移除元件的第一开口的第一端部（14a）的柔性袋（14）。 该袋包括可与隔离系统接合的传送端口（26），用于将灭菌的元件传送到隔离系统中。 输送口具有延伸通过其的孔（30）。 孔的外表面（28）具有夹具接收区域（32）和凹槽（34）。 袋的第一端位于凹槽中。 夹具（38）位于第一端附近的柔性袋周围。 柔性袋的一部分夹在夹具和传送口上的夹具接收区之间。 密封材料（44）位于凹槽中并且封装柔性袋的第一端以形成密封。

公开(公告)号：WO1993023305A1

公开(公告)日：1993-11-25

申请号：PCT/US1993004366

申请日：1993-05-07

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  MC QUAY, Gary, E.

IPC: B65D41/48

CPC classification number: B65D41/48

Abstract: A container device (10) comprising a tubular container (11) and a closure member (13). The tubular container includes an open upper terminal end. The tubular container has a radially extending outwardly facing annular ring (25) located at a point axially inward from the upper terminal end of the tubular container. The outwaardly facing annular ring includes a first plurality of outwardly facing ribs (27). The closure member includes a second plurality of ribs (31) inwardly facing for mating with the first plurality of ribs and being sized to prevent axial rotation between the container and the closure member when the first and second pluralities of ribs are mated. The closure member includes a cap portion which is sized to engage the upper terminal end of the tubular container with the cap portion being mounted on the closure member in part by a hinge and in part a tear-off band having a pull tab. The container includes an outwardly extending flange (33) proximate the first plurality of outwardly facing ribs for engagement with a groove (35) on the closure member. The groove is sized to snap fit into the flange to prevent separation of the container and the closure member. The tear-off (15) band and the hinge (17) are located between the flange/groove assembly and the open terminal end of the container.

Abstract translation: 一种容器装置（10），包括管状容器（11）和封闭构件（13）。 管状容器包括开放的上部终端。 管状容器具有径向延伸的向外的环形环（25），该环形环位于从管状容器的上端部轴向向内的点处。 面向外的环形环包括第一多个向外的肋（27）。 所述封闭构件包括第二多个肋（31），所述第二多个肋（31）向内面对以与所述第一多个肋配合，并且当所述第一和第二多个肋配合时，所述肋的尺寸设计成防止所述容器和所述封闭构件之间的轴向旋转。 封闭构件包括盖部分，其尺寸适于与管状容器的上端部接合，帽部分由铰链部分地安装在封闭构件上，并且部分地通过拉片安装在撕开带上。 容器包括靠近第一多个向外的肋的向外延伸的凸缘（33），用于与封闭构件上的凹槽（35）接合。 凹槽的尺寸适于卡扣配合到凸缘中以防止容器和封闭构件分离。 撕开（15）带和铰链（17）位于凸缘/槽组件和容器的敞开的终端之间。

公开(公告)号：WO1995025042A1

公开(公告)日：1995-09-21

申请号：PCT/US1995003430

申请日：1995-03-16

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  MAIETTA, Michel ,  FRAZIER, Thomas, A.

IPC: B65D17/42

CPC classification number: B65D5/748 ,  B65D77/067

Abstract: A closure assembly (30) for piercing a diaphragm (24) over a discharge opening (22) in a container (10) comprising a cap of cup-like form (32) having internal thread means (43) and a generally tubular spout member (34) mounted on the container (10) surrounding the diaphragm (24) and a piercing fitment (36) disposed interiorly of the spout member (34) having a series of depending teeth (39) arranged in a circular array and cooperating interengaging means between the spout member (34) and piercing fitment (36) and cap (32) whereby rotational movement of the cap (32) in one direction effects downward displacement of the piercing fitment (36) to pierce the diaphragm (24).

Abstract translation: 一种用于将隔膜（24）穿过容器（10）中的排出口（22）的封闭组件（30），该容器包括具有内螺纹装置（43）的杯状形式（32）的帽和大致管状的喷口构件 （34），其安装在围绕隔膜（24）的容器（10）上;以及穿孔配件（36），其设置在喷口构件（34）的内部，该穿孔配件具有布置成圆形阵列的一系列悬挂齿（39），并配合相互接合装置 在喷嘴构件（34）和穿孔配件（36）和盖（32）之间，由此盖（32）在一个方向上的旋转运动实现穿孔配件（36）向下移动以刺穿隔膜（24）。

公开(公告)号：WO1994003373A1

公开(公告)日：1994-02-17

申请号：PCT/US1993007435

申请日：1993-08-06

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  YATSKO, Thomas ,  OLIVAS, Jerome, deLeon ,  VANDER BUSH, Edward, F. ,  CONARD, William, A. ,  JEPSON, Steven, C. ,  DUDAR, Thomas, E.

IPC: B65D51/00

CPC classification number: B65D51/222 ,  A61J1/1406 ,  A61J1/201 ,  A61J1/2096 ,  B65D51/002 ,  B65D2251/0015 ,  B65D2251/0056 ,  B65D2251/009 ,  Y10S215/03

Abstract: Disclosed is a stopper for use with containers to provide needleless access to the container with a cannula having a blunt penetrating tip. Also disclosed is a system comprising the stopper, container and cannula. The stopper includes a disc (29) having an upper face (31) and a lower face (33), and a plug (27) extending from the disc into the container. Also included is a diaphragm (37), defined by a target region in the upper face and a cross channel (41) in the disc for controlling the force needed to penetrate the stopper with the cannula. The plug includes a first inward surface (43) for guiding the cannula and a second inward suface (45) for engaging the cannula to minimize wetting of the outside of the cannula. In a preferred embodiment, the first surface (43) extends down from the cross channel (41) on the lower side of the disc, radially outwardly to a maximum diameter and the second inwardly facing surface (45) extends down from the first surface radially inwardly to a minimum diameter to form the cannula seal. Also shown is a centrally located piercing point positioned to pre-slit the diaphragm. An overcap may be provided to alternatively have an axially aligned boss and bore positioned to pre-slit the diaphragm. In another embodiment, the invention includes an annular pre-slit disc (59) formed of self sealing material and positioned to reduce spray back when inserting or removing the cannula.

Abstract translation: 公开了一种用于与容器一起使用具有钝的穿透尖端的套管来无菌地进入容器的塞子。 还公开了一种包括塞子，容器和套管的系统。 止动器包括具有上表面（31）和下表面（33）的盘（29）和从盘延伸到容器中的塞子（27）。 还包括由上表面中的目标区域和盘中的横向通道（41）限定的隔膜（37），用于控制用套管渗透塞子所需的力。 塞子包括用于引导套管的第一向内表面（43）和用于接合插管的第二内表面（45），以最小化套管外部的湿润。 在优选实施例中，第一表面（43）从盘的下侧的交叉通道（41）向下延伸，径向向外延伸至最大直径，并且第二向内表面（45）从第一表面向下延伸 向内至最小直径以形成套管密封。 还示出了定位成预先切割隔膜的位于中心的穿刺点。 可以提供顶盖以备选地具有轴向对齐的凸台和孔，以便预先切割隔膜。 在另一个实施例中，本发明包括由自密封材料形成并定位成在插入或移除插管时减少喷雾的环形预切割盘（59）。

公开(公告)号：WO1993009058A1

公开(公告)日：1993-05-13

申请号：PCT/US1992009375

申请日：1992-10-29

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  MAIETTA, Michael, G.

IPC: B67D05/32

CPC classification number: B65D47/2018

Abstract: A device comprising a tube (11) having an opening terminating in a nozzle (21) with an open end and having threads (23) for rotational engagement with a cap (17); the device also comprising a check valve (37a). The cap is sized to engage the nozzle at its open end and has a closed terminal end having a first inwardly facing, axially centered locating cup (31) for engagement with the open end of the nozzle, and a second inwardly facing, axially centered sealing cup (29) for engagement with the open end of the nozzle to form a seal in the nozzle open end. Finally, the cap and tube have a cooperative ring (35) and groove (25) to provide a signal upon full engagement of the cap and tube.

Abstract translation: 一种包括管（11）的装置，其具有终止于具有开口端的喷嘴（21）中的开口，并具有用于与帽（17）旋转接合的螺纹（23）。 所述装置还包括止回阀（37a）。 盖的尺寸被设计成在其开口端处接合喷嘴，并且具有封闭的末端，其具有用于与喷嘴的开口端接合的第一向内面对的轴向居中定位杯（31），以及第二向内面对的轴向中心密封 杯（29）用于与喷嘴的开口端接合以在喷嘴开口端形成密封。 最后，盖和管具有合作环（35）和凹槽（25），以在盖和管完全接合时提供信号。

公开(公告)号：WO1998009579A1

公开(公告)日：1998-03-12

申请号：PCT/US1997007232

申请日：1997-05-01

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  DURKEE, Jeffrey, W.

IPC: A61B19/00

CPC classification number: B65D51/002 ,  B65D47/08

Abstract: A reclosable (10) for a vial (12) having a neck portion (14) with a sealing flange (16) surrounding an open end (18) thereof, is provided. The reclosable closure (10) comprises a metal shell (20), having a top portion (22) with an opening (24) defined therethrough, and a depending sidewall portion (28) sized to engage the flange (16) of the vial (12). A plastic top (34) is provided having a top portion (36) which overlies the top portion (22). The plastic top (34) has an outer skirt (40) which overlies the depending sidewall portion (28). The inner wall (42) has a first portion (44) which extends through the opening (24), and a second portion (46) which extends outwardly from the first portion (44). A reclosable cover (52) is rotatably attached to the top (34). The cover (52) is rotatable on a hinge (54) between a closed position and an open position.

Abstract translation: 提供了一种用于具有颈部（14）的小瓶（12）的可再封闭（10），所述颈部具有围绕其开口端（18）的密封凸缘（16）。 可再闭合闭合件（10）包括金属壳（20），其具有顶部（22），其中限定有开口（24），以及垂直侧壁部分（28），其尺寸适于接合小瓶的凸缘（16） 12）。 塑料顶部（34）设置有顶部（36），该顶部覆盖在顶部部分（22）上。 塑料顶部（34）具有覆盖在悬垂侧壁部分（28）上的外裙部（40）。 内壁（42）具有延伸穿过开口（24）的第一部分（44）和从第一部分（44）向外延伸的第二部分（46）。 可重新闭合的盖（52）可旋转地附接到顶部（34）。 盖（52）可在关闭位置和打开位置之间的铰链（54）上旋转。

公开(公告)号：WO1994004424A1

公开(公告)日：1994-03-03

申请号：PCT/US1993007850

申请日：1993-08-20

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  FOLTA, Christopher, M. ,  ANES, John, M. ,  BROWN, Homer, J.

IPC: B65D41/18

CPC classification number: B65D51/241

Abstract: A closure device for use with a container (11) having an open neck finish, including an inner cap (21) having a skirt (27) terminating in an open end which engages the outside diameter (D1) of the finish. The inner cap (21) is sized to initially engage the finish. The skirt (27) has circumferentially spaced slits (33) extending, which may function as lyophilization ports, which permit the inner cap (21) to expand upon an axial closing force and engage the bottom of the finish. A liner (19) is positioned in the inner cap (21) proximate the closed end and is compressed against the finish when the cap is moved to alignment with the bottom of the finish. An outer cap (17) is locked on to the inner cap (21) in pre-assembly which then encloses the inner cap (21) after complete assembly to seal and compress the liner (19) between the finish (43) and the inside face of the inner cap (21). In a preferred embodiment, an inwardly facing ridge (35) is located on the inside of the inner cap (21) to engage the liner (19) by a distance sufficient to permit the liner (19) to seal to the finish (43) over the maximum variation of dimensions for the liner (19) and for the crown on the finish (43).

Abstract translation: 一种封闭装置，用于具有开口颈部精整的容器（11），包括内盖（21），所述内盖（21）具有终止于端面的端部（27），所述裙部（27）终止于端面的外径（D1）。 内盖（21）的尺寸设计成最初接合完成。 裙部（27）具有延伸的周向间隔开的狭缝（33），其可以用作冻干口，其允许内盖（21）在轴向闭合力下膨胀并接合完成物的底部。 衬套（19）靠近封闭端定位在内盖（21）中，并且当盖移动到与表面的底部对准时被压靠在表面上。 外盖（17）在预组装中被锁定到内盖（21）上，然后在完全组装之后封闭内盖（21），以密封和压缩在完成物（43）和内部 内盖（21）的表面。 在优选实施例中，向内的脊（35）位于内盖（21）的内侧，以使衬套（19）接合足以允许衬套（19）密封到精加工（43）的距离， 超过衬套（19）和表面（43）上的表冠的最大尺寸变化。

公开(公告)号：WO1992013011A1

公开(公告)日：1992-08-06

申请号：PCT/US1992000149

申请日：1992-01-09

Applicant: THE WEST COMPANY, INCORPORATED

Inventor： THE WEST COMPANY, INCORPORATED ,  HARWOOD, H. James ,  JANES, Allan, S. ,  SMOOK, Malcolm, A.

IPC: C08F08/10

CPC classification number: C08F8/10 ,  C08F8/00 ,  C08F297/00

Abstract: A thermoplastic elastomeric block copolymer comprising olefin elastomeric mid block units and terminal polystyrene units having acylation substitution in an amount sufficient to raise the glass transition temperature of the polymer. The acylation substitution comprises cycloaliphatic or aromatic acylation and the acylation substitution is accomplished by reaction of an acylhalide with the copolymer in the presence of a catalytic amount of triflic acid.

Abstract translation: 一种包含烯烃弹性体中间嵌段单元和末端聚苯乙烯单元的热塑性弹性体嵌段共聚物，其具有足以提高聚合物的玻璃化转变温度的量的酰化取代。 酰化取代包括脂环族或芳族酰化，并且酰化取代通过酰基卤与共聚物在催化量的三氟甲酸的存在下反应来完成。