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    PROCESS FOR PRODUCING O,O`-DIACYLTARTARIC ANHYDRIDE AND O,O`-DIACYLTARTARIC ACID
    1.
    发明专利
    PROCESS FOR PRODUCING O,O`-DIACYLTARTARIC ANHYDRIDE AND O,O`-DIACYLTARTARIC ACID 未知

    公开(公告)号：HUT69765A

    公开(公告)日：1995-09-28

    申请号：HU9303396

    申请日：1993-11-30

    Applicant: TORAY INDUSTRIES

    Inventor： SATO HARUYO ,  NAKAI SAKIE ,  FUJINO TOSHIHIRO

    IPC: C07D307/56 ,  C07C67/52 ,  C07C69/70 ,  C07C69/76 ,  C07C69/78 ,  C07D307/60

    Abstract: Crystals of an aromatic 0,0'-diacyltartaric acid of the formula (VIII): wherein R and R are the same as or different from one another and each is a hydrogen atom, halogen atom or C1 - C4 alkyl group are sufficiently uniform in size that 95% to 98% of them pass through a 20-mesh sieve. Such crystals may be prepared by hydrolyzing an aromatic carboxylic anhydride of the formula (IV): wherein R and R are as defined above, to form the corresponding acid (VIII) in the form of an oil and crystallizing the acid in the presence of an organic solvent which is immiscible with water to form crystals of the hydrate of the acid (VIII). For the crystallization process, each of the organic solvent immiscible with water and seed crystals of the acid (VIII) are added to the oil of the acid (VIII) present in the reaction mixture.

    PROCESS FOR PRODUCING O,O'-DIACYLTARTARIC ANHYDRIDE AND O,O'-DIACYL-TARTARIC ACID
    2.
    发明专利
    PROCESS FOR PRODUCING O,O'-DIACYLTARTARIC ANHYDRIDE AND O,O'-DIACYL-TARTARIC ACID 未知

    公开(公告)号：HU9303396D0

    公开(公告)日：1994-03-28

    申请号：HU9303396

    申请日：1993-11-30

    Applicant: TORAY INDUSTRIES

    Inventor： SATO HARUYO ,  NAKAI SAKIE ,  FUJINO TOSHIHIRO

    IPC: C07D307/56 ,  C07C67/52 ,  C07C69/70 ,  C07C69/76 ,  C07C69/78

    Abstract: Crystals of an aromatic 0,0'-diacyltartaric acid of the formula (VIII): wherein R and R are the same as or different from one another and each is a hydrogen atom, halogen atom or C1 - C4 alkyl group are sufficiently uniform in size that 95% to 98% of them pass through a 20-mesh sieve. Such crystals may be prepared by hydrolyzing an aromatic carboxylic anhydride of the formula (IV): wherein R and R are as defined above, to form the corresponding acid (VIII) in the form of an oil and crystallizing the acid in the presence of an organic solvent which is immiscible with water to form crystals of the hydrate of the acid (VIII). For the crystallization process, each of the organic solvent immiscible with water and seed crystals of the acid (VIII) are added to the oil of the acid (VIII) present in the reaction mixture.

    4.
    发明专利
    未知

    公开(公告)号：DE69326050T2

    公开(公告)日：2000-02-03

    申请号：DE69326050

    申请日：1993-11-30

    Applicant: TORAY INDUSTRIES

    Inventor： SATO HARUYO ,  NAKAI SAKIE ,  FUJINO TOSHIHIRO

    IPC: C07D307/56 ,  C07C67/52 ,  C07C69/70 ,  C07C69/76 ,  C07C69/78 ,  C07C67/08 ,  C07C67/14 ,  C07C67/28

    Abstract: Crystals of an aromatic 0,0'-diacyltartaric acid of the formula (VIII): wherein R and R are the same as or different from one another and each is a hydrogen atom, halogen atom or C1 - C4 alkyl group are sufficiently uniform in size that 95% to 98% of them pass through a 20-mesh sieve. Such crystals may be prepared by hydrolyzing an aromatic carboxylic anhydride of the formula (IV): wherein R and R are as defined above, to form the corresponding acid (VIII) in the form of an oil and crystallizing the acid in the presence of an organic solvent which is immiscible with water to form crystals of the hydrate of the acid (VIII). For the crystallization process, each of the organic solvent immiscible with water and seed crystals of the acid (VIII) are added to the oil of the acid (VIII) present in the reaction mixture.

    6.
    发明专利
    未知

    公开(公告)号：DE69326050D1

    公开(公告)日：1999-09-23

    申请号：DE69326050

    申请日：1993-11-30

    Applicant: TORAY INDUSTRIES

    Inventor： SATO HARUYO ,  NAKAI SAKIE ,  FUJINO TOSHIHIRO

    IPC: C07D307/56 ,  C07C67/52 ,  C07C69/70 ,  C07C69/76 ,  C07C69/78 ,  C07C67/08 ,  C07C67/14 ,  C07C67/28

    Abstract: Crystals of an aromatic 0,0'-diacyltartaric acid of the formula (VIII): wherein R and R are the same as or different from one another and each is a hydrogen atom, halogen atom or C1 - C4 alkyl group are sufficiently uniform in size that 95% to 98% of them pass through a 20-mesh sieve. Such crystals may be prepared by hydrolyzing an aromatic carboxylic anhydride of the formula (IV): wherein R and R are as defined above, to form the corresponding acid (VIII) in the form of an oil and crystallizing the acid in the presence of an organic solvent which is immiscible with water to form crystals of the hydrate of the acid (VIII). For the crystallization process, each of the organic solvent immiscible with water and seed crystals of the acid (VIII) are added to the oil of the acid (VIII) present in the reaction mixture.

    PROCESS FOR PREPARING OPTICALLY ACTIVE 2-PIPERAZINECARBOXYLIC ACID DERIVATIVES
    7.
    发明公开
    PROCESS FOR PREPARING OPTICALLY ACTIVE 2-PIPERAZINECARBOXYLIC ACID DERIVATIVES 失效
    VERFAHREN ZUR HERSTELLUNG VON OPTISCH AKTIVEN 2-PIPERAZINCARBONSUREURE DERIVATEN

    公开(公告)号：EP0906906A4

    公开(公告)日：2002-01-02

    申请号：EP96943334

    申请日：1996-12-27

    Applicant: TORAY INDUSTRIES

    Inventor： FUJINO TOSHIHIRO ,  SATO HARUYO

    IPC: C07D241/04 ,  C07B57/00 ,  C07C233/46 ,  C07C233/83 ,  C07C271/22 ,  C07C311/04 ,  C07C311/06 ,  C07C311/08

    CPC classification number: C07D241/04

    Abstract: A process for preparing optically active piperazinecarboxylic acid derivatives by the resolution of diastereomeric salts wherein an optically active acidic amino acid derivative is used as the agent for optical resolution to thereby enhance the recovery of the agent and the production efficiency. N-Acyl and N-sulfonyl derivatives of optically active acidic amino acids are usable as the above optically active acidic amino acid derivatives.

    Abstract translation: 通过使用光学活性的酸性氨基酸衍生物作为拆分试剂，通过非对映异构体盐分解制备光学活性的2-哌嗪羧酸衍生物。 在该方法中，所使用的拆分试剂的回收率高，生产光学活性物质的生产效率高。 作为光学活性的酸性氨基酸衍生物，可以使用光学活性的N-酰化酸性氨基酸衍生物和光学活性的N-磺酰化酸性氨基酸衍生物。

    PRODUCTION METHOD OF OPTICALLY ACTIVE PIPERIDINE DERIVATIVE AND ITS ACID SALT
    10.
    发明专利
    PRODUCTION METHOD OF OPTICALLY ACTIVE PIPERIDINE DERIVATIVE AND ITS ACID SALT 失效

    公开(公告)号：JP2002193933A

    公开(公告)日：2002-07-10

    申请号：JP2001171606

    申请日：2001-06-06

    Applicant: TORAY INDUSTRIES

    Inventor： FUJINO TOSHIHIRO ,  SATO HARUYO

    IPC: C07D211/30 ,  C07B57/00 ,  C07C69/76

    Abstract: PROBLEM TO BE SOLVED: To obtain an optically active piperidine derivative, especially optically active 3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine or its acid salt with high optical purity in high yield. SOLUTION: The production method of the optically active piperidine derivative, especially optically active 3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine or its acid salt in which an optically active O,O'-diacyltartaric acid is used as an optically resolving reagent.

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